JLB Vol 110 Issue 2 TOC

Cover Image Journal of Leukocyte Biology
Volume 110, Issue 2
Focus Issue: Targeted Science — Special Focus Issue

Pages: 207-398

August 2021



Free Access
Issue Information

Pages: 207-211 | First Published: 28 July 2021


Starting‐NOX2‐Up: Rac unrolls p67phox
Jamel El-Benna, Pham My-Chan Dang

Pages: 213-215 | First Published: 16 May 2021

Graphical Abstract

Discussion on the molecular mechanism of phagocyte NADPH oxidase activation.

Can you teach an old receptor new tricks?
Carsten Alexander Raabe, Ursula Rescher

Pages: 217-218 | First Published: 06 November 2020

Graphical Abstract

Discussion on biased agonism of the human formyl peptide receptor 1 (FPR1) for precision therapeutic targeting of neutrophil function.


The molecular basis of Rac‐GTP action—promoting binding of p67phox to Nox2 by disengaging the β hairpin from downstream residues
Edna Bechor, Anat Zahavi, Yevgeny Berdichevsky, Edgar Pick

Pages: 219-237 | First Published: 15 April 2021

Graphical Abstract

Deletion of residues 181-193 or severing the bond between Q115 and K181 enhances binding of p67phox to Nox2 residues 369-383, mimicking the effect of Rac-GTP

2020 Annual Meeting of the Zhejiang Society of Immunology

Guest Editors: Linrong Lu, Lie Wang, Di Wang, Yushi Yao, Weilin Chen


Follicular regulatory T cell biology and its role in immune‐mediated diseases
Yishan Ye, Mowang Wang, He Huang

Pages: 239-255 | First Published: 03 May 2021

Graphical Abstract

Reviews advances in Tfr cell biology and highlights the current understanding of Tfr cells involvement in autoimmunity and alloreactivity.

Open Access
Metabolic reprogramming of myeloid‐derived suppressor cells: An innovative approach confronting challenges
Xiaoqing Li, Yixue Li, Qinru Yu, Pengxu Qian, He Huang, Yu Lin

Pages: 257-270 | First Published: 02 June 2021

Graphical Abstract

This work intends to declare what metabolic alterations happen in MDSCs to support their physiologic and functional demands under a variety of pathologic situations.

Shanghai: Frontiers in Immunology Science in Major Human Diseases and Treatment

Guest Editors: Yiwei Chu, Yuejuan Zheng, Chunfang Gao, Wei Xu, Hanchen Xu, Feifei Luo


Gut microbiota shape B cell in health and disease settings
Baichao Yu, Luman Wang, Yiwei Chu

Pages: 271-281 | First Published: 11 May 2021

Graphical Abstract

Review on gut microbiota and its impact on shaping the host B cells; which, in turn, regulates gut microbiota diversity and function.

The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke
Jinman Chen, Linmei Wang, Hao Xu, Yongjun Wang, Qianqian Liang

Pages: 283-291 | First Published: 22 April 2021

Graphical Abstract

Review of how stroke affects the lymphatic drainage system of the CNS and its function in immune response and lymphatic drainage after stroke.


STAT5 promotes chronic pancreatitis by enhancing GM‐CSF‐dependent neutrophil augmentation
Yuli Lin, Yusheng Chen, Wenxue Feng, Junfeng Zhang, Rong Hua, Bo Yin, Xuguang Yang

Pages: 293-300 | First Published: 28 June 2021

Graphical Abstract

Up-regulated expression and activation of STAT5 increases GM-CSF expression, promotes neutrophil augmentation, and eventually exacerbates chronic pancreatitis.

IFNγ‐mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells
Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu

Pages: 301-314 | First Published: 28 July 2021

Graphical Abstract

Shows IFN gamma is an effective modulator in inhibiting EMT-associated growth of HCC via inducing ferroptosis, providing new insight into the use of IFN gamma for cancer treatment.

Tanshinone IIA enhances susceptibility of non‐small cell lung cancer cells to NK cell‐mediated lysis by up‐regulating ULBP1 and DR5
Yufang Sun, Chenyuan Gong, Zhongya Ni, Dan Hu, Wanyi Ng, Xiaowen Zhu, Lixin Wang, Guifan Si, Xuewei Yan, Chen Zhao, Chao Yao, Shiguo Zhu

Pages: 315-325 | First Published: 28 April 2021

Graphical Abstract

TIIA up-regulated ULBP1 and DR5 by activating ER stress signaling and then enhanced the susceptibility of NSCLC cells to NK cell-mediated lysis

Blood tests predict the therapeutic prognosis of anti‐PD‐1 in advanced biliary tract cancer
Fei Du, Zhiquan Qiu, Wenchao Ai, Chenjun Huang, Jun Ji, Xiao Xiao, Jun Zhou, Meng Fang, Xiaoqing Jiang, Chunfang Gao

Pages: 327-334 | First Published: 16 March 2021

Graphical Abstract

Peripheral blood indicators including IP-10, MIP-1β, NLR and SII were associated with anti-PD-1 treatment response and prognosis in advanced biliary tract cancer patients.

Decreased levels of immune‐regulatory cytokines in patients with immune thrombocytopenia and long‐lasting overexpression of these cytokines in the splenectomized patients
Xiaofeng Wang, Feng Li, Yang Li, Lihua Sun, Yahong Meng, Xiaohong Fan, Xuelian Wang, Duojiao Wu, Yunfeng Cheng, Fanli Hua

Pages: 335-341 | First Published: 28 July 2021

Graphical Abstract

Decreased immune-regulatory cytokines in patients with ITP can be restored after successful treatment, and dramatically increased after splenectomy.


Open Access
Inducing regulated necrosis and shifting macrophage polarization with anti‐EMMPRIN antibody (161‐pAb) and complement factors
Nizar Hijaze, Max Ledersnaider, Elina Simanovich, Sameer Kassem, Michal A. Rahat

Pages: 343-356 | First Published: 17 November 2020

Graphical Abstract

Anti-EMMPRIN antibody and complement factors kill tumor cells by necroptosis, releasing dsRNA, thus polarizing macrophages to change the TME and induce anti-tumor IFN response

Open Access
Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN‐λ3 or IFN‐λ4 show distinct phenotypes
Manjarika De, Anand Bhushan, Sreedhar Chinnaswamy

Pages: 357-374 | First Published: 17 November 2020

Graphical Abstract

Human IFN-λ3 and IFN-λ4 modulate the differentiation of monocytes into macrophages and dendritic cells and influence their phenotypes.

Annexin A2 regulates unfolded protein response via IRE1–XBP1 axis in macrophages during P. aeruginosa infection
Chuan-Min Zhou, Li-Mei Luo, Ping Lin, Qinqin Pu, Biao Wang, Shugang Qin, Qun Wu, Xue-Jie Yu, Min Wu

Pages: 375-384 | First Published: 22 November 2020

Graphical Abstract

AnxA2 plays a role in IRE1–XBP1 pathway of ER stress induced by P. aeruginosa infection through inhibition of phospho–p38 MAPK.


Persons who inject drugs (PWID) retain functional NK cells, dendritic cell stimulation, and adaptive immune recall responses despite prolonged opioid use
Costin Tomescu, Krystal Colon, Peter Smith, Mack Taylor, Livio Azzoni, David S. Metzger, Luis J. Montaner

Pages: 385-396 | First Published: 02 December 2020

Graphical Abstract

Long-term opioid drug users have evidence of increased immune activation but no detectable immune dysfunction in NK, DC, and T cell responses measured ex vivo, nor increased susceptibility to in vitro HIV infection.


Free Access
Flow cytometric evaluation of the neutrophil compartment in COVID‐19 at hospital presentation: A normal response to an abnormal situation

Pages: 397-398 | First Published: 28 July 2021