JLB Early View

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue

MEETING REVIEWS

Neuroimmune interactions in painful TMD: Mechanisms and treatment implications
Yating Yi, Xueman Zhou, Xin Xiong, Jun Wang

Version of Record online: 29 July 2021


Graphical Abstract

Reviews neuro-immune interactions that influence TMD pain sensitization and chronicity; describes the implications this has for treatment.

EDITORIAL COMMENTARY

TREM2 splicing emerges as crucial aspect to understand TREM2 biology
Miguel Moutinho, Gary E. Landreth

Version of Record online: 27 July 2021


Graphical Abstract

Discussion on TREM2 splicing and its different transcripts with regard to the physiological function of TREM2 and its role in disease.

ARTICLES

The interaction between iNKT cells and B cells
Tong Zhu, Rongli Wang, Heather Miller, Lisa S. Westerberg, Lu Yang, Fei Guan, Pamela Lee, Quan Gong, Yan Chen, Chaohong Liu

Version of Record online: 27 July 2021


Graphical Abstract

Reviews the interaction between invariant natural killer T cells (iNKTs) and B cells and their impact on the treatment of infections, autoimmune diseases, cancers, and other diseases.

Open Access

ARTICLES

Hemin‐primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles
Yujiao Wu, Qianying Yu, Meng Zhang, Yao Zhou, Xiao Su, Min Wu, Jiajia Lv, Zhenwei Xia

Version of Record online: 23 July 2021


Graphical Abstract

Hemin-induced heme oxygenase (HO)-1 alleviates asthmatic airway inflammation by dendritic cells (DCs)-released extracellular vesicles (DCEVs).

HIGHLIGHTED ARTICLE

Identification of altered cell signaling pathways using proteomic profiling in stable and progressive chronic lymphocytic leukemia
Cristina Bagacean, Cristina Adela Iuga, Anne Bordron, Adrian Tempescul, Ioana-Ecaterina Pralea, Delphine Bernard, Melanie Cornen, Tiffany Bergot, Christelle Le Dantec, Wesley Brooks, Hussam Saad, Jean-Christophe Ianotto, Jacques-Olivier Pers, Mihnea Zdrenghea, Christian Berthou, Yves Renaudineau

Version of Record online: 20 July 2021


Graphical Abstract

Proteomic profiles at the early stage of CLL can discriminate progressive from stable disease and RNA splicing and cell cycle dysregulation underlies CLL evolution; opening new perspectives on potential biomarkers and therapy.

EDITORIAL COMMENTARY

Small but potent: GTPases as novel players on the neutrophils autophagy market
Joanna Koziel, Maciej Lech

Version of Record online: 20 July 2021


Graphical Abstract

GEM, small GTPase from the RGK family, serves as significant negative regulator of neutrophils' activity.

ARTICLES

FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate‐conditioned and diabetic macrophages
Priya Gupta, Gaurav Sharma, Amit Lahiri, Manoj Kumar Barthwal

Version of Record online: 20 July 2021


Graphical Abstract

In palmitate-conditioned wild type and diabetic mice macrophages, FOXO3a acetylation inhibits PINK1 expression and mitophagy leading to enhanced mtROS, mtDNA release, and inflammasome activation.

ARTICLES

miR‐181c regulates MCL1 and cell survival in GATA2 deficient cells
Weixin Wang, Rui Chen, Stephenie Droll, Emily Barber, Layla Saleh, Meghan Corrigan-Cummins, Megan Trick, Vollter Anastas, Nga Voong Hawk, Zhen Zhao, Donald C. Vinh, Amy Hsu, Dennis D. Hickstein, Steven M. Holland, Katherine R. Calvo

Version of Record online: 16 July 2021


Graphical Abstract

GATA2 deficiency leads to increased miR-181c, decreased MCL1, and enhanced cell death which may contribute to phenotypic features of cytopenia, immunodeficiency, and bone marrow failure.

Open Access

MEETING ARTICLES

Macrophage inflammatory state influences susceptibility to lysosomal damage
Amanda O. Wong, Matangi Marthi, Amanda Haag, Irene A. Owusu, Christiane E. Wobus, Joel A. Swanson

Version of Record online: 14 July 2021


Graphical Abstract

TLR and cytokine stimulation increase macrophage resistance to lysosomal damage through multiple distinct signaling pathways.

ARTICLES

Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation
Beilei Liang, Haicheng Wang, Di Wu, Zuolin Wang

Version of Record online: 12 July 2021


Graphical Abstract

Macrophage phenotype dynamically changes after dental implantation, and affects the process of osseointegration via paracrine effects

ARTICLES

LncRNA NEAT1_1 suppresses tumor‐like biologic behaviors of fibroblast‐like synoviocytes by targeting the miR‐221‐3p/uPAR axis in rheumatoid arthritis
Manli Wang, Yixiong Chen, Xuan Bi, Xiqing Luo, Zuoyu Hu, Yan Liu, Xiaoyi Shi, Weizhen Weng, Biyao Mo, Yan Lu, Yunfeng Pan

Version of Record online: 12 July 2021


Graphical Abstract

Urokinase-type plasminogen activator receptor and the function of nuclear paraspeckle assembly transcript 1 _1 in regulating rheumatoid arthritis fibroblast-like synoviocytes.

Open Access

ARTICLES

Identification of HLA‐A2 restricted CD8+ T cell epitopes in SARS‐CoV‐2 structural proteins
Jieping Deng, Junping Pan, Minghui Qiu, Lipeng Mao, Zhigang Wang, Guodong Zhu, Lijuan Gao, Jun Su, Yutian Hu, Oscar Junhong Luo, Guobing Chen, Pengcheng Wang

Version of Record online: 07 July 2021


Graphical Abstract

Identifies CD8+ T cell epitopes in SARS-CoV-2 structural proteins, helping to further define specific immune responses that could aid in vaccine development for SARS-CoV-2.

MEETING REVIEW

Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved
Hui Yu, Anqi Zhou, Jiayi Liu, Yufei Tang, Quan Yuan, Yi Man, Lin Xiang

Version of Record online: 07 July 2021


Graphical Abstract

Review of potential systemic risk factors in dental implant therapy, including advice for novice clinicians.

ARTICLES

The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase‐induced mesangial cell proliferation
Yuxuan Zhen, Tracy L. McGaha, Fred D. Finkelman, Wen-Hai Shao

Version of Record online: 04 July 2021


Graphical Abstract

Axl mediates mesangial cell phagocytosis of apoptotic cells and promotes mesangial cell proliferation by activating NF-kB and mTORC1.

EDITORIAL

Yo GABA GABA! A neurotransmitter interrupts DC‐NK crosstalk
Michael H. Askenase

Version of Record online: 01 July 2021


Graphical Abstract

Discussion on GABA as a key player in mediating neuroimmune communications between NK cells and DC.