JLB Vol 110 Issue 3 TOC

Cover Image Journal of Leukocyte Biology
Volume 110, Issue 3
Focus Issue: Targeted Science — Special Focus Issue

Pages: 399-604

September 2021



Free Access
Issue Information

Pages: 399-403 | First Published: 26 August 2021


What a difference ADA2 makes: Insights into the pathophysiology of ADA2 deficiency from single‐cell RNA sequencing of monocytes
Lisa Ehlers, Isabelle Meyts

Pages: 405-407 | First Published: 16 June 2021

Graphical Abstract

Discussion on the increase in nonclassical monocytes in patients with DADA2 as shown by scRNA seq; these pro inflammatory cells also show increased TNFR2, type I, and type II IFN pathway gene expression.


Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single‐cell RNA sequencing of monocytes
Naoki Watanabe, Shouguo Gao, Zhijie Wu, Sai Batchu, Sachiko Kajigaya, Carrie Diamond, Lemlem Alemu, Diego Quinones Raffo, Patrycja Hoffmann, Deborah Stone, Amanda K. Ombrello, Neal S. Young

Pages: 409-424 | First Published: 14 May 2021

Graphical Abstract

Elevated IFNγ activates cell signaling, leading to differentiation into M1 macrophages from monocytes and release of TNFα.

Free Access
Severe COVID‐19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin
Rodolfo Soria-Castro, Yatsiri G. Meneses-Preza, Gloria M. Rodríguez-López, Sandra Romero-Ramírez, Víctor A. Sosa-Hernández, Rodrigo Cervantes-Díaz, Alfredo Pérez-Fragoso, José J. Torres-Ruíz, Diana Gómez-Martín, Marcia Campillo-Navarro, Violeta D. Álvarez-Jiménez, Sonia M. Pérez-Tapia, Alma D. Chávez-Blanco, Sergio Estrada-Parra, José L. Maravillas-Montero, Rommel Chacón-Salinas

Pages: 425-431 | First Published: 31 May 2021

Graphical Abstract

Serum levels of CPA3 and serotonin are affected during SARS-CoV-2 infection and can be considered as biomarkers during COVID-19.

Society of Oral Biomedical Annual Conference 2020

Guest Editors: Yan Jin, Zhi Wang, Jianbo Sun, Yi Liu, Zhengwei Huang


Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation
Beilei Liang, Haicheng Wang, Di Wu, Zuolin Wang

Pages: 433-447 | First Published: 12 July 2021

Graphical Abstract

Macrophage phenotype dynamically changes after dental implantation, and affects the process of osseointegration via paracrine effects

Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector‐mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair
Di Cui, Changxing Chen, Binyan Luo, Fuhua Yan

Pages: 449-459 | First Published: 14 May 2021

Graphical Abstract

Demonstrates the therapeutic efficiency of PHD2 gene interference in osteogenic differentiation and periodontal defect repair for highly efficient periodontal regeneration.


Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis
Niu Zhou, Fagui Zou, Xiao Cheng, Yilian Huang, Hang Zou, Qingru Niu, Yi Qiu, Fen Shan, Aoxiang Luo, Wei Teng, Jianbo Sun

Pages: 461-473 | First Published: 31 May 2021

Graphical Abstract

P. gingivalis stimulates experimental periodontitis; induces immune dysregulation, especially downregulation of B10 cells; and enhances pathogenesis of collagen-induced arthritis.


The effect of an isoquinoline alkaloid on treatment of periodontitis by regulating the neutrophils chemotaxis
Yitong Liu, Huan Xia, Guiyang Xia, Sheng Lin, Lijia Guo, Yi Liu

Pages: 475-484 | First Published: 28 June 2021

Sustained calcium ion release from bioceramics promotes CaSR‐mediated M2 macrophage polarization for osteoinduction
Jinglun Zhang, Qian Wu, Chengcheng Yin, Xiaoshi Jia, Zifan Zhao, Xiaoxin Zhang, Guohua Yuan, Hao Hu, Qin Zhao

Pages: 485-496 | First Published: 28 June 2021

Graphical Abstract

Macrophages are indispensable in the process of BCP-induced new bone formation, where M2 macrophages are promoted through the sustained supply of BCP-released Ca2+ to CaSR.

Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis
Lulingxiao Nie, PengFei Zhao, Ziqi Yue, Peng Zhang, Ning Ji, Qianming Chen, Qi Wang

Pages: 497-510 | First Published: 04 June 2021

Graphical Abstract

The pyroptosis caused by diabetes leads to the dysfuntion of macrophages and the establishment of a pro-inflammatory, pre-aging microenvironment.

The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment in P. gingivalis LPS‐induced periodontitis mice
Xu Zhang, Xuan Zhang, Che Qiu, Hui Shen, Huanyu Zhang, Zhiyan He, Zhongchen Song, Wei Zhou

Pages: 511-524 | First Published: 03 August 2021

Graphical Abstract

P. gingivalis LPS-induced periodontitis may promote the occurrence and progression of cognitive impairment by modulating the Th17/Treg balance inside and outside the brain.


The microbiota‐gut‐bone axis and bone health
Ye Tu, Ran Yang, Xin Xu, Xuedong Zhou

Pages: 525-537 | First Published: 22 April 2021

Graphical Abstract

Review on the correlations between gut microbiota and bone metabolism and associated underlying mechanisms.

Immunomodulatory functions of oral mesenchymal stem cells: Novel force for tissue regeneration and disease therapy
Lingling Shang, Jinlong Shao, Shaohua Ge

Pages: 539-552 | First Published: 28 June 2021

Graphical Abstract:

Neuroimmune interactions in painful TMD: Mechanisms and treatment implications
Yating Yi, Xueman Zhou, Xin Xiong, Jun Wang

Pages: 553-563 | First Published: 29 July 2021

Graphical Abstract

Reviews neuro-immune interactions that influence TMD pain sensitization and chronicity; describes the implications this has for treatment.

Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms
Zhiyu Zhang, Mengting Deng, Meng Hao, Jianxia Tang

Pages: 565-576 | First Published: 27 May 2021

Graphical Abstract

Review of the interactions and potential mechanisms between resident PDLSCs and periodontitis niche for maintaining periodontal homeostasis.

Intersection between macrophages and periodontal pathogens in periodontitis
Wenzhe Wang, Chenxi Zheng, Jianhua Yang, Bei Li

Pages: 577-583 | First Published: 24 May 2021

Graphical Abstract

Reviews the anti-inflammation and pro-inflammation mechanisms of macrophages in periodontitis with bacterial infection.

TCF‐1 maintains CD8+ T cell stemness in tumor microenvironment
Shuqiong Wen, Huanzi Lu, Dikan Wang, Junyi Guo, Wenxiao Dai, Zhi Wang

Pages: 585-590 | First Published: 28 May 2021

Graphical Abstract

Summarizes recent studies showing that intratumoral exhausted CD8+ T cell-expressed TCF-1 is a unique subset; possesses stem cell-like properties that improve both antitumor immunity and the response to immune-checkpoint blockade.

Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved
Hui Yu, Anqi Zhou, Jiayi Liu, Yufei Tang, Quan Yuan, Yi Man, Lin Xiang

Pages: 591-604 | First Published: 07 July 2021

Graphical Abstract

Review of potential systemic risk factors in dental implant therapy, including advice for novice clinicians.