JLB Vol 110, Issue 4 eTOC

Cover Image Journal of Leukocyte Biology
Volume 110, Issue 4

Pages: 605-819

October 2021



Free Access
Issue Information

Pages: 605-609 | First Published: 29 September 2021


Yo GABA GABA! A neurotransmitter interrupts DC‐NK crosstalk
Michael H. Askenase

Pages: 611-612 | First Published: 01 July 2021

Graphical Abstract

Discussion on GABA as a key player in mediating neuroimmune communications between NK cells and DC.

Small but potent: GTPases as novel players on the neutrophils autophagy market
Joanna Koziel, Maciej Lech

Pages: 613-615 | First Published: 20 July 2021

Graphical Abstract

GEM, small GTPase from the RGK family, serves as significant negative regulator of neutrophils' activity.


Open Access
GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii
Amol K. Bhandage, Laura M. Friedrich, Sachie Kanatani, Simon Jakobsson-Björkén, J. Ignacio Escrig-Larena, Arnika K. Wagner, Benedict J. Chambers, Antonio Barragan

Pages: 617-628 | First Published: 24 May 2021

Graphical Abstract

In response to infection challenge, NK cells synthesize and secrete gamma-aminobutyric acid (GABA), which impacts NK cell and dendritic cell functions via GABA-A receptors.

The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy
Jennifer L. Johnson, Mahalakshmi Ramadass, Farhana Rahman, Elsa Meneses-Salas, Nadia R. Zgajnar, Raquel Carvalho Gontijo, Jinzhong Zhang, William B. Kiosses, Yanfang Peipei Zhu, Catherine C. Hedrick, Marta Perego, Jenny E. Gunton, Kersi Pestonjamasp, Gennaro Napolitano, Sergio D. Catz

Pages: 629-649 | First Published: 04 June 2021

Graphical Abstract

Deficiency of the small GTPase Gem slows down the autophagic flux in stimulated neutrophils, causing autophagosome accumulation and autophagosome-associated NADPH complex assembling, leading to increased ROS and NETs formation.


LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR‐25‐3p/SIRT6 pathway
Wei Qian, Ze-qi Zheng, Jun-gang Nie, Li-juan Liu, Xiang-zhu Meng, Hong Sun, Feng-ming Xiao, Ting Kang

Pages: 651-661 | First Published: 19 January 2021

Graphical Abstract

LncRNA SNHG12 alleviates vascular endothelial injury in Ang II-induced hypertension through miR-25-3p/SIRT6 pathway.


Exogenous ATP modulates PGE2 release in macrophages through sustained phosphorylation of CDK9 and p38 MAPK
Shamima Akter, Rakesh Kumar Sharma, Shilpa Sharma, Saumya Rastogi, Bernd L. Fiebich, Ravi Shankar Akundi

Pages: 663-677 | First Published: 13 January 2021

Graphical Abstract

Exogenous ATP enhances LPS-mediated PGE2 release in macrophages by sustaining a high level of COX-2 mRNA through extended phosphorylation of CDK9 and p38 MAPK.

Differential expression of Triggering Receptor Expressed on Myeloid cells 2 (Trem2) in tissue eosinophils
Albert C. Sek, Caroline M. Percopo, Arun K. Boddapati, Michelle Ma, Wendy E. Geslewitz, Julia O. Krumholz, Justin B. Lack, Helene F. Rosenberg

Pages: 679-691 | First Published: 06 January 2021

Graphical Abstract

The flexibility of eosinophil gene expression profiles in vivo supports the LIAR hypothesis of eosinophil function.


Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition
Hamza Ali, Ramon Caballero, Simon X.M. Dong, Niranjala Gajnayaka, Agatha Vranjkovic, Duale Ahmed, Salma Iqbal, Angela M. Crawley, Jonathan B. Angel, Edana Cassol, Ashok Kumar

Pages: 693-710 | First Published: 06 January 2021

Graphical Abstract

IAPs regulate the survival of pro- and anti-inflammatory human macrophages and targeting the IAPs and/or caspases can be exploited to control inflammation-related disorders

Open Access
Mesenchymal stromal cells expressing a dominant‐negative high mobility group A1 transgene exhibit improved function during sepsis
Min-Young Kwon, Sailaja Ghanta, Julie Ng, Ana P. Castano, Junwen Han, Bonna Ith, James A. Lederer, Souheil El-Chemaly, Su Wol Chung, Xiaoli Liu, Mark A. Perrella

Pages: 711-722 | First Published: 13 January 2021

Graphical Abstract

Administration of adipose-derived MSCs expressing a dominant-negative HMGA1 transgene results in less tissue injury and inflammation during a systemic infection, while improving neutrophil phagocytosis.


Immune checkpoint markers and anti‐CD20‐mediated NK cell activation
Zhaoming Wang, George J. Weiner

Pages: 723-733 | First Published: 08 December 2020

Graphical Abstract

Activation by anti-CD20 mAb upregulates NK cell TIGIT and TIM3 expression but has minimal effect on NK cell phenotype or function.


Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells
Maaike R. Scheenstra, Patricia Martínez-Botía, Andrea Acebes-Huerta, Rutger W.W. Brouwer, Noemí Caballero-Sánchez, Nynke Gillemans, Pieter De Bleser, Benjamin Nota, Iris M. De Cuyper, Vishal Salunkhe, Andrea M. Woltman, Lianne van de Laar, Erikjan Rijkers, Jeroen A.A. Demmers, Wilfred F.J. van IJcken, Sjaak Philipsen, Timo K. van den Berg, Taco W. Kuijpers, Laura Gutiérrez

Pages: 735-751 | First Published: 02 December 2020

Graphical Abstract

Comparing human and mouse PU.1 regulome and interactome in inflammatory DCs reveals species-specific responses and conserved regulatory features of PU.1.


Open Access
The spleen: “epicenter” in malaria infection and immunity
Debopam Ghosh, Jason S. Stumhofer

Pages: 753-769 | First Published: 19 January 2021

Graphical Abstract

Reviews the spleen's function during malaria infection; shows how this organ serves as a central hub for activating and exerting effector mechanisms within the immune response to control blood-stage infection with Plasmodium parasites.

IL‐34 and CSF‐1, deciphering similarities and differences at steady state and in diseases
Antoine Freuchet, Apolline Salama, Séverine Remy, Carole Guillonneau, Ignacio Anegon

Pages: 771-796 | First Published: 18 February 2021

Graphical Abstract

Review comparing IL-34 and CSF-1, including their biochemistry, biology, and roles in diseases; highlighting new areas of research and potential therapies.

The vitals of NETs
Chuyi Tan, Monowar Aziz, Ping Wang

Pages: 797-808 | First Published: 30 December 2020

Graphical Abstract

Review of mechanisms of neutrophil extracellular traps (NETs) formation, including the impact of NETs on individual organs as well as the limitations and advantages of NETs detection assays in use today.

Free Access
Role of vitamin D in regulating COVID‐19 severity—An immunological perspective
Vandana Kalia, George P. Studzinski, Surojit Sarkar

Pages: 809-819 | First Published: 19 January 2021

Graphical Abstract

Review on Vitamin D-dependent immunoregulatory mechanisms underlying respiratory disease severity in SARS-CoV2 infections.