JLB Early View October 2021

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue

MEETING ARTICLES

A review of the mechanisms of keratinocytes damage caused by Staphylococcus aureus infection in patients with atopic dermatitis
Xin Tian, Qiongxiao Huang, Jingyao Liang, Jianqin Wang, Jing Zhang, Yan Yang, Qianru Ye, Suling He, Junlong Li, Zhouwei Wu, Yumei Liu

Version of Record online: 29 September 2021


Graphical Abstract

Review of the mechanisms underlying the immune and inflammatory damage from keratinocytes caused by S. aureus; may help guide treatment options for patients with atopic dermatitis.

ARTICLES

LncRNA SNHG8 sponges miR‐449c‐5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood‐brain barrier permeability in ischemic stroke
Duobin Zhang, Ning Pan, Chuan Jiang, Maolin Hao

Version of Record online: 29 September 2021


Graphical Abstract

SNHG8 reduced microglia activation and blood-brain barrier permeability via the miR-449c-5p/SIRT1/SIRT1/FoxO1 pathway, thus playing a protective role in ischemic brain injury.

HIGHLIGHTED ARTICLE

Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae‐induced pneumonia
Qing Rong Li, Shi Rui Tan, Lu Yang, Wei He, Li Chen, Fen Xiu Shen, Zhuo Wang, Hai Feng Wang

Version of Record online: 29 September 2021


Graphical Abstract

Examines the functional mechanism of CA in AM polarization in detail and provides a theoretical basis for treatment of Klebsiella pneumoniae (Kp)-induced pneumonia.

Open Access

ARTICLES

Loss of mTORC2‐induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators
Maryam Jangani, Juho Vuononvirta, Lamya Yamani, Eleanor Ward, Melania Capasso, Suchita Nadkarni, Frances Balkwill, Federica Marelli-Berg

Version of Record online: 29 September 2021


Graphical Abstract

mTORC2-dependent Akt activation is instrumental for metabolic reprogramming at the early stages-migration and differentiation-of macrophage-mediated immunity.

ARTICLES

Dynamic changes in human single‐cell transcriptional signatures during fatal sepsis
Xinru Qiu, Jiang Li, Jeff Bonenfant, Lukasz Jaroszewski, Aarti Mittal, Walter Klein, Adam Godzik, Meera G. Nair

Version of Record online: 24 September 2021


Graphical Abstract

Single cell transcriptomics of peripheral blood mononuclear cells in surviving and fatal sepsis reveal inflammatory and metabolic pathways that change within hours of sepsis recognition.

REVIEW

The emerging therapeutic potential of extracellular vesicles in trauma
Nijmeh Alsaadi, Amudan J. Srinivasan, Anupamaa Seshadri, Matthew Shiel, Matthew D. Neal, Melanie J. Scott

Version of Record online: 17 September 2021


Graphical Abstract

Review of current extracellular vesicle-based treatment modalities in hemostasis, inflammation, acute lung injury, traumatic brain injury, and spinal cord injury following trauma, and potential for the future.

ARTICLES

BCG‐trained innate immunity leads to fetal growth restriction by altering immune cell profile in the mouse developing placenta
Yipu Dang, Camille Souchet, Fabiana Moresi, Mohamed Jeljeli, Bruno Raquillet, Carole Nicco, Sandrine Chouzenoux, Isabelle Lagoutte, Louis Marcellin, Frederic Batteux, Ludivine Doridot

Version of Record online: 17 September 2021


Graphical Abstract

BCG immune training before pregnancy led to IUGR in mice by modifying immune cell frequency in the developing placenta, whereas LPS training had no effect

ARTICLES

Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin‐dependent phagosome maturation
Siwei Mo, Xiaoqian Liu, Kehong Zhang, Wenfei Wang, Yi Cai, Qi Ouyang, Chuanzhi Zhu, Dachuan Lin, Haoqiang Wan, Dechang Li, Zhihua Wen, Xinchun Chen

Version of Record online: 17 September 2021


Graphical Abstract

Flunarizine limits Mycobacterium tuberculosis growth in macrophages by promoting CaM-pCAMKII-mediated phagolysosome maturation.

REVIEW

Signaling networks in B cell development and related therapeutic strategies
Anwen Ren, Jianxuan Sun, Wei Yin, Lisa S. Westerberg, Heather Miller, Pamela Lee, Fabio Candotti, Fei Guan, Jiahui Lei, Quan Gong, Yan Chen, Chaohong Liu

Version of Record online: 16 September 2021


Graphical Abstract

Reviews several essential and recently discovered signaling pathways in B cell development; takes a look at diseases related to aberrant signals as well as newly developed strategies for treating these diseases.

REVIEW

Role of extracellular vesicles in atherosclerosis: An update
Pierre-Michaël Coly, Chantal M. Boulanger

Version of Record online: 08 September 2021


Graphical Abstract

Review of the role of extracellular vesicles during the different phases of atherosclerotic lesion development that describes the need to standardize isolation and analysis procedures to fully realize their potential as biomarkers and therapeutics for cardiovascular diseases.

ARTICLES

Mitofusin‐2 regulates leukocyte adhesion and β2 integrin activation
Wei Liu, Alan Y. Hsu, Yueyang Wang, Tao Lin, Hao Sun, Joel S. Pachter, Alex Groisman, Matthew Imperioli, Fernanda Wajnsztajn Yungher, Liang Hu, Penghua Wang, Qing Deng, Zhichao Fan

Version of Record online: 08 September 2021


Graphical Abstract

Identification of MFN2 as a key regulator of leukocyte adhesion, integrin activation, actin polymerization, and maturation.

ARTICLES

Peony seed oil ameliorates neuroinflammation‐mediated cognitive deficits by suppressing microglial activation through inhibition of NF‐κB pathway in presenilin 1/2 conditional double knockout mice
Jie Gao, Lijun Wang, Chenyi Zhao, Yongkang Wu, Zhiyuan Lu, Yining Gu, Zongtao Ba, Xingyu Wang, Jian Wang, Ying Xu

Version of Record online: 08 September 2021


Graphical Abstract

Peony seed oil suppressed microglial activation and neuroinflammation through the downregulation of pro-inflammatory mediators in the prefrontal cortex and hippocampus of PS cDKO mice, and lessened memory impairment by reversing hyperphosphorylated tau and synaptic proteins deficits.

MEETING ARTICLES

Differential role of TNFR1 and TNFR2 in the development of imiquimod‐induced mouse psoriasis
Shaokui Chen, Zibei Lin, Long Xi, Ying Zheng, Qiong Zhou, Xin Chen

Version of Record online: 08 September 2021


Graphical Abstract

TNFR1 is pathogenic while TNFR2 plays a protective role in the development of psoriasis in the mouse model of psoriasis induced by imiquimod.

Free Access

Review - COVID-19 and Related Topics

Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine‐induced thrombotic thrombocytopenia (VITT)
Junaid Kashir, Ayesha Rahman Ambia, Areez Shafqat, Muhammad Raihan Sajid, Khaled AlKattan, Ahmed Yaqinuddin

Version of Record online: 01 September 2021


Graphical Abstract

Review on the scientific premise for incidence of vaccine-induced thrombotic thrombocytopenia as a result of inflammatory reactions mediated via IL-1β/NLRP3 inflammasome activation and consequent overproduction of NETs.

REVIEWS

Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?
Jian-Da Lin, P'ng Loke

Version of Record online: 01 September 2021


Graphical Abstract

Reviews helminth infection's impact on the immune system and the microbiota; provides mechanistic insight that may aid in finding new approaches for treating cardiovascular disease.