Discussion on TREM2 splicing and its different transcripts with regard to the physiological function of TREM2 and its role in disease.

A novel TREM2 splicing isoform constitutes up to 35 percent of transcript repertoire in human brain and encodes protein with activities different from the canonic isoform

Arhgef6 (alpha-PIX) inhibits signaling to GTPases and Cofilin to restrain lamellipodia formation, cell turning, and cell migration speed.

Expression of iNOS positively regulates imatinib response in BCR-ABL+ cells and monitoring its level could help to identify patients likely to be responsive or resistant to imatinib.

ICOS-induced downmodulation of ICOS-L involving endocytosis and trans-endocytosis controls ICOS-L levels and can regulate immune responses that are dependent on ICOS costimulation

Insulin activates the metabolism of primary human monocytes and induces a pro-inflammatory phenotype, including increased pro-inflammatory cytokine secretion and ROS production and migration.

MIF and MIF-2 prolong neutrophil survival only in the presence of mononuclear cells and/or CXCL8 via a predominantly CXCR2-dependent mechanism.

IL-38 inhibits the induction of innate immune memory

Neutrophils (PMN) regulate inflammation in many ways, including communication with other immune cells via extracellular vesicles (EVs).

Sodium houttuyfonate primes intestinal macrophage by inducing β-glucan exposure and attenuating Candida albicans-associated colitis through Dectin-1/TLR2/TLR4 interactions.

A longitudinal analysis of infant MDSC frequency and association with vaccine antigen recall responses. PMN-MDSC present at infant vaccination reduces the probability of cellular IFN-g release, but not proliferation or antibody production, upon subsequent ex-vivo vaccine-specific antigenic stimulation.

Adenovirus-delivered antimicrobial peptide administration constitutes a promising adjuvant therapy for current anti-TB drugs by enhancing a protective immune response and potentially reducing current antibiotic regimes' duration.

Review on full-length membrane-bound FasL and the soluble FasL cleavage product playing distinct and often opposing roles in the immunoregulation of ocular pathology.

Review on microRNAs, their impact on intestine barrier integrity and potential for therapeutic intervention to manage gut barrier integrity in GI related pathological conditions.

HMGB1 acts as an alarmin to induce the inflammatory response, and is involved in progression of liver disease through binding to its receptors.