JLB Vol 110 Issue 5 TOC
Cover Image Journal of Leukocyte Biology
Volume 110, Issue 5

Pages: 821-998

November 2021



Free Access
Issue Information

Pages: 821-825 | First Published: 25 October 2021


TREM2 splicing emerges as crucial aspect to understand TREM2 biology
Miguel Moutinho, Gary E. Landreth

Pages: 827-828 | First Published: 27 July 2021

Graphical Abstract

Discussion on TREM2 splicing and its different transcripts with regard to the physiological function of TREM2 and its role in disease.


Novel TREM2 splicing isoform that lacks the V‐set immunoglobulin domain is abundant in the human brain
Kostantin Kiianitsa, Irina Kurtz, Neal Beeman, Mark Matsushita, Wei-Ming Chien, Wendy H. Raskind, Olena Korvatska

Pages: 829-837 | First Published: 01 June 2021

Graphical Abstract

A novel TREM2 splicing isoform constitutes up to 35 percent of transcript repertoire in human brain and encodes protein with activities different from the canonic isoform


Open Access
Arhgef6 (alpha‐PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence
Dejan Mamula, Mark Korthals, Johannes Hradsky, Anna Gottfried, Klaus-Dieter Fischer, Kerry Tedford

Pages: 839-852 | First Published: 02 February 2021

Graphical Abstract

Arhgef6 (alpha-PIX) inhibits signaling to GTPases and Cofilin to restrain lamellipodia formation, cell turning, and cell migration speed.

Expression of inducible NOS is indispensable for the antiproliferative and proapoptotic effect of imatinib in BCR–ABL positive cells
Abhishek Kumar Singh, Deepika Awasthi, Megha Dubey, Sheela Nagarkoti, Tulika Chandra, Manoj Kumar Barthwal, Anil Kumar Tripathi, Madhu Dikshit

Pages: 853-866 | First Published: 02 February 2021

Graphical Abstract

Expression of iNOS positively regulates imatinib response in BCR-ABL+ cells and monitoring its level could help to identify patients likely to be responsive or resistant to imatinib.


Open Access
Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand
Laura Aragoneses-Fenoll, María Montes-Casado, Gloria Ojeda, Lucía García-Paredes, Yutaka Arimura, Junji Yagi, Umberto Dianzani, Pilar Portolés, José M. Rojo

Pages: 867-884 | First Published: 02 February 2021

Graphical Abstract

ICOS-induced downmodulation of ICOS-L involving endocytosis and trans-endocytosis controls ICOS-L levels and can regulate immune responses that are dependent on ICOS costimulation


Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype
Jacqueline M. Ratter, Julia I. P. van Heck, Hanne M. M. Rooijackers, Henry J. Jansen, Pleun C. M. van Poppel, Cees J. Tack, Rinke Stienstra

Pages: 885-891 | First Published: 21 January 2021

Graphical Abstract

Insulin activates the metabolism of primary human monocytes and induces a pro-inflammatory phenotype, including increased pro-inflammatory cytokine secretion and ROS production and migration.

Open Access
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells
Lisa Schindler, Leon Zwissler, Christine Krammer, Ulrike Hendgen-Cotta, Tienush Rassaf, Mark B. Hampton, Nina Dickerhof, Jürgen Bernhagen

Pages: 893-905 | First Published: 10 February 2021

Graphical Abstract

MIF and MIF-2 prolong neutrophil survival only in the presence of mononuclear cells and/or CXCL8 via a predominantly CXCR2-dependent mechanism.

Open Access
IL‐38 prevents induction of trained immunity by inhibition of mTOR signaling
Dennis M. de Graaf, Lisa U. Teufel, Frank L. van de Veerdonk, Leo A. B. Joosten, Mihai G. Netea, Charles A. Dinarello, Rob J. W. Arts

Pages: 907-915 | First Published: 23 February 2021

Graphical Abstract

IL-38 inhibits the induction of innate immune memory

Neutrophil‐derived extracellular vesicles modulate the phenotype of naïve human neutrophils
Maya F. Amjadi, Benjamin S. Avner, Mallary C. Greenlee-Wacker, Alexander R. Horswill, William M. Nauseef

Pages: 917-925 | First Published: 08 March 2021

Graphical Abstract

Neutrophils (PMN) regulate inflammation in many ways, including communication with other immune cells via extracellular vesicles (EVs).


Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β‐glucan exposure
Kelong Ma, Mengli Chen, Juanjuan Liu, Yuzhu Ge, Tianming Wang, Daqiang Wu, Guiming Yan, Changzhong Wang, Jing Shao

Pages: 927-937 | First Published: 08 March 2021

Graphical Abstract

Sodium houttuyfonate primes intestinal macrophage by inducing β-glucan exposure and attenuating Candida albicans-associated colitis through Dectin-1/TLR2/TLR4 interactions.


Myeloid‐derived suppressor cells and their association with vaccine immunogenicity in South African infants
Elvis Kidzeru, Melanie A. Gasper, Danica Shao, Paul T. Edlefsen, Nicholas Lejarcegui, Enock Havyarimana, Kevin Urdahl, Soren Gantt, Helen Horton, Heather Jaspan, Ana Gervassi

Pages: 939-950 | First Published: 21 January 2021

Graphical Abstract

A longitudinal analysis of infant MDSC frequency and association with vaccine antigen recall responses. PMN-MDSC present at infant vaccination reduces the probability of cellular IFN-g release, but not proliferation or antibody production, upon subsequent ex-vivo vaccine-specific antigenic stimulation.


Immunotherapeutic effect of adenovirus encoding antimicrobial peptides in experimental pulmonary tuberculosis
Octavio Ramos-Espinosa, Dulce Mata-Espinosa, Alejandro Francisco-Cruz, Manuel Othoniel López-Torres, Sujhey Hernández-Bazán, Jorge Barrios-Payán, Brenda Marquina-Castillo, Marta Carretero, Marcela del Río, Rogelio Hernández-Pando

Pages: 951-963 | First Published: 08 March 2021

Graphical Abstract

Adenovirus-delivered antimicrobial peptide administration constitutes a promising adjuvant therapy for current anti-TB drugs by enhancing a protective immune response and potentially reducing current antibiotic regimes' duration.


The FasLane to ocular pathology—metalloproteinase cleavage of membrane‐bound FasL determines FasL function
Meredith Gregory-Ksander, Ann Marshak-Rothstein

Pages: 965-977 | First Published: 10 February 2021

Graphical Abstract

Review on full-length membrane-bound FasL and the soluble FasL cleavage product playing distinct and often opposing roles in the immunoregulation of ocular pathology.

Maintenance of gut barrier integrity after injury: Trust your gut microRNAs
Niya L. Morris, Mashkoor A. Choudhry

Pages: 979-986 | First Published: 12 February 2021

Graphical Abstract

Review on microRNAs, their impact on intestine barrier integrity and potential for therapeutic intervention to manage gut barrier integrity in GI related pathological conditions.


HMGB1: An overview of its roles in the pathogenesis of liver disease
Yuan-Ao Ni, Hui Chen, Hao Nie, Bing Zheng, Quan Gong

Pages: 987-998 | First Published: 30 March 2021

Graphical Abstract

HMGB1 acts as an alarmin to induce the inflammatory response, and is involved in progression of liver disease through binding to its receptors.