Free Access
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19
Nathaniel L. Lartey, Salvador Valle-Reyes, Hilda Vargas-Robles, Karina E. Jiménez-Camacho, Idaira M. Guerrero-Fonseca, Ramón Castellanos-Martínez, Armando Montoya-García, Julio García-Cordero, Leticia Cedillo-Barrón, Porfirio Nava, Jessica G. Filisola-Villaseñor, Daniela Roa-Velázquez, Dan I Zavala-Vargas, Edgar Morales-Ríos, Citlaltepetl Salinas-Lara, Eduardo Vadillo, Michael Schnoor
Version of Record online:26 November 2021
Graphical Abstract
Inhibition of ADAM17 with apratastat or TMI-1 ameliorates neutrophilia and cytokine storm in a mouse model of Covid-19-related lung injury induced by poly(I:C) and the receptor-binding domain of the SARS-CoV2 Spike protein (RBD-S).
IRF3 inhibits IFN‐γ‐mediated restriction of intracellular pathogens in macrophages independently of IFNAR
Karolina Maciag, Raktima Raychowdhury, Karen Smith, Alexis M. Schneider, Jörn Coers, Maxwell R. Mumbach, Schraga Schwartz, Nir Hacohen
Version of Record online:26 November 2021
Graphical Abstract
IRF3 modulates multiple responses of IFNγ-primed macrophages to intracellular bacteria, including production of nitric oxide; meanwhile, IFNγ reciprocally inhibits IRF3, contributing to immune homeostasis.
Open Access
Human macrophage polarization shapes B. pertussis intracellular persistence
Hugo A. Valdez, Jose L. Marin Franco, Juan P. Gorgojo, Jimena Alvarez Hayes, Luciana Balboa, Marcelo Fernandez Lahore, María C. Sasiain, Maria Eugenia Rodriguez
Version of Record online:23 November 2021
Graphical Abstract
B. pertussis is able to survive within both M1 and M2 macrophages but M2c proved to be the best suited subtype for bacterial intracellular persistence.
The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms
Divya Ramnath, Kaustav Das Gupta, Yizhuo Wang, Rishika Abrol, James E. B. Curson, Junxian Lim, Robert C. Reid, Ashley Mansell, Antje Blumenthal, Denuja Karunakaran, David P. Fairlie, Matthew J. Sweet
Version of Record online:23 November 2021
Graphical Abstract
Demonstration that TLR-inducible Hdac7 enzymatic activity is required for inducible cytokine production in murine macrophages, whereas it instructs inducible glycolysis independently of enzyme activity.
Open Access
CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag‐presenting capacity and antitumor potency
Paul Burgoyne, Alan J Hayes, Rachel S Cooper, Michelle L Le Brocq, Christopher AH Hansell, John DM Campbell, Gerard J Graham
Version of Record online:15 November 2021
Graphical Abstract
Selection of CCR7+ DCs using chemically synthesized and tagged CCL19 selects a population of DC which improves anti-tumour immunity and efficacy in solid and metastatic tumour models.
Effects of TNF‐α deletion on iNKT cell development, activation, and maturation in the steady‐state and chronic alcohol‐consuming mice
Hui Zhang, Faya Zhang, Samantha Modrak
Version of Record online:12 November 2021
Graphical Abstract
TNF-a plays an important role in iNKT cell development, activation and maturation, and chronic alcohol consumption enhances iNKT cell activation and maturation through TNF-a.
Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases
Mrigya Babuta, Gyongyi Szabo
Version of Record online:10 November 2021
Graphical Abstract
Extracellular vesicle-associated miRNAs alter the immune response by inter-cellular and inter-organ communication and thereby contribute to the pathobiology of various liver diseases.
Open Access
PAD4 controls chemoattractant production and neutrophil trafficking in malaria
Drinalda Cela, Sebastian Lorenz Knackstedt, Sarah Groves, Christopher M. Rice, Jamie Tae Wook Kwon, Benjamin Mordmüller, Borko Amulic
Version of Record online:10 November 2021
Graphical Abstract
PAD4 promotes malaria immunopathology by regulating chemokine production in macrophages and enhancing recruitment of inflammatory cells.
Free Access
Platelet extracellular vesicles in COVID‐19: Potential markers and makers
Florian Puhm, Louis Flamand, Eric Boilard
Version of Record online:03 November 2021
Graphical Abstract
Review on platelet extracellular vesicles (pEVs); includes a special focus on pEV's potential as predictors of and contributors to COVID-19.
Identification of liver‐specific CD24+ invariant NK T cells with low granzyme B production and high proliferative capacity
Xiang Li, Chen Jin, Qi Chen, Xihua Zheng, Di Xie, Qielan Wu, Lu Wang, Shiyu Bai, Huimin Zhang, Li Bai
Version of Record online:03 November 2021
Graphical Abstract
Hepatic CD24+ iNKT cells show higher levels of proliferation, glucose metabolism and mTOR activity comparing to CD24- iNKT cells
Free Access
T follicular helper cells in the humoral immune response to SARS‐CoV‐2 infection and vaccination
Marios Koutsakos, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Jennifer A Juno
Version of Record online:03 November 2021
Graphical Abstract
Review on the analysis of TFH cells during COVID-19 infection and vaccination and the role of these cells as biomarkers of neutralising antibody development.
Single‐cell profiling of T lymphocytes in deficiency of adenosine deaminase 2
Zhijie Wu, Shouguo Gao, Naoki Watanabe, Sai Batchu, Sachiko Kajigaya, Carrie Diamond, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Patrycja Hoffmann, Deborah Stone, Amanda Ombrello, Neal S. Young
Version of Record online:03 November 2021
Graphical Abstract
T lymphocytes are activated and actively involved in DADA2 pathogenesis; and ligand-receptor crosstalk with monocytes likely leads to up-regulation of STAT1 and subsequently augmented responses of cells to IFN upon stimulation.