JLB Vol 110 Issue 6

Cover Image Journal of Leukocyte Biology
Volume 110, Issue 6
Focus Issue: Targeted Science — Special Focus Issue

Pages: 999-1278

December 2021



Free Access
Issue Information

Pages: 999-1004 | First Published:29 November 2021


Peony seed oil ameliorates neuroinflammation‐mediated cognitive deficits by suppressing microglial activation through inhibition of NF‐κB pathway in presenilin 1/2 conditional double knockout mice
Jie Gao, Lijun Wang, Chenyi Zhao, Yongkang Wu, Zhiyuan Lu, Yining Gu, Zongtao Ba, Xingyu Wang, Jian Wang, Ying Xu

Pages: 1005-1022 | First Published:08 September 2021

Graphical Abstract

Peony seed oil suppressed microglial activation and neuroinflammation through the downregulation of pro-inflammatory mediators in the prefrontal cortex and hippocampus of PS cDKO mice, and lessened memory impairment by reversing hyperphosphorylated tau and synaptic proteins deficits.

Adoptive transfer of GRP78‐treated dendritic cells alleviates insulitis in NOD mice
Xiaoqi Zhou, Muyang Yang, Yibing Lv, Heli Li, Sha Wu, Jie Min, Guanxin Shen, Yong He, Ping Lei

Pages: 1023-1031 | First Published:13 October 2021

Graphical Abstract

Adoptively transferred GRP78-DCs, specifically homed to the inflamed pancreas, can promote beta cell survival, alleviate insulitis, and resolve inflammation in NOD mice.

2020 Annual Meeting of Immune Cell Biology, Chinese Society for Immune Cell Biology (CSCB)

Guest Editors: Lilin Ye, Qizhao Huang, Duojiao Wu, Hanjie Li


Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function
Minghang Yu, Ziyang Su, Xuefeng Huang, Yujie Zhou, Xulong Zhang, Bingbing Wang, Zihan Wang, Yi Liu, Nianzeng Xing, Miaoran Xia, Xi Wang

Pages: 1033-1045 | First Published:23 August 2021

Graphical Abstract

Deletion of Ezh2 promotes NK cell terminal differentiation and cytotoxicity with increased IFN-γ production by a potential target Pbx1.

Differential role of TNFR1 and TNFR2 in the development of imiquimod‐induced mouse psoriasis
Shaokui Chen, Zibei Lin, Long Xi, Ying Zheng, Qiong Zhou, Xin Chen

Pages: 1047-1055 | First Published:08 September 2021

Graphical Abstract

TNFR1 is pathogenic while TNFR2 plays a protective role in the development of psoriasis in the mouse model of psoriasis induced by imiquimod.

Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Lin Li, Yuting Xia, Shijie Yuan, Fei Li, Xiaorong Xie, Yuan Luo, Xiang-Ping Yang, Ran He

Pages: 1057-1067 | First Published:06 October 2021

Graphical Abstract

Blocking iron intake by anti-CD71 mAb impaired the response of TH17 cells, ameliorating autoimmune disease severity.


Tumor immunology in the age of single‐cell genomics
Lingyu Zhao, Lili Ren, Shuangshu Gao, Jun Wang, Xiaobo Li, Lei Zhang, Yuanyuan Zhu, Hanjie Li

Pages: 1069-1079 | First Published:28 June 2021

Graphical Abstract

Discussion on how single-cell technology advances tumor immunology and immunotherapy research.

Targeting T cell metabolism for immunotherapy
Jie Gao, Yanbo Liu, Jian Wei, Linlan Jiang, Jianwen Mao, Chih-Hao Chang, Duojiao Wu

Pages: 1081-1090 | First Published:15 November 2021

Graphical Abstract

Review on the relationship between T-cell metabolism and cell function and the potential new strategies to enhance immunotherapy by regulating T-cell metabolism.

2020 Annual Meeting of the Guangdong Society for Immunology

Guest Editors: Zhinan Yin, Jianlei Hao, and Jun Chen


Structural characteristics of coiled‐coil regions in AF10‐DOT1L and AF10‐inhibitory peptide complex
Zhechong Zhou, Sisi Kang, Zhaoxia Huang, Ziliang Zhou, Shoudeng Chen

Pages: 1091-1099 | First Published:16 May 2021

Graphical Abstract

Structure-based optimization of the inhibitory peptide against AF10 provides an innovative pharmacologic basis for therapeutic intervention in leukemia.

ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage
Xikui Sun, Meiling Liu, Jingning Bai, Jiejie Xu, Chengming Zhu, Junchao Dong, Chun Chen

Pages: 1101-1112 | First Published:22 April 2021

Graphical Abstract

Unlike ATM, ATR kinase activity promotes both c-NHEJ and A-EJ-mediated CSR through cell cycle regulation but not suppression of DSB resection and MH usage

Sinomenine increases adenosine A2A receptor and inhibits NF‐κB to inhibit arthritis in adjuvant‐induced‐arthritis rats and fibroblast‐like synoviocytes through α7nAChR
Lang Yi, Junyu Ke, Jiayan Liu, Huili Lai, Yanjun Lv, Chong Peng, Yingkun Zhi, Qun Du, Liang Liu, Peixun Wang, Hua Zhou, Yan Dong

Pages: 1113-1120 | First Published:23 August 2021

Graphical Abstract

Sinomenine increased adenosine receptor A2A and inhibited the activation of the NF-κB pathway via the alpha7 nicotinic acetylcholine receptor in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes.

Gut microbiota contributes to sexual dimorphism in murine autoimmune cholangitis
Meng-Xing Huang, Si-Yu Yang, Pan-Yue Luo, Jie Long, Qing-Zhi Liu, Jinjun Wang, Yi He, Liang Li, Zhi-Bin Zhao, Zhe-Xiong Lian

Pages: 1121-1130 | First Published:28 May 2021

Graphical Abstract

Testosterone-independent and gut microbiota-mediated sexual differences were identified in a murine model of primary biliary cholangitis.

High mobility group box‐1 serves a pathogenic role in spinal cord injury via the promotion of pro‐inflammatory cytokines
Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying Ma

Pages: 1131-1142 | First Published:17 August 2021

Graphical Abstract

HMGB1 served an important role in SCI inflammation and the therapeutic potential of an anti-HMGB1 antibody for SCI.

Polymorphonuclear myeloid‐derived suppressor cells link inflammation and damage response after trauma
Xinyao Li, Jingping Liu, Zhe Xing, Jian Tang, Hengbiao Sun, Xiaogang Zhang, Shuaijun Lv, Ziyang Chen, Mengyu Shi, Meiqi Chen, Shaowen Zuo, Xiaoming Lyu, Yumei He

Pages: 1143-1161 | First Published:12 October 2021

Graphical Abstract

Role of PMN-MDSCs in the anti-inflammatory immune response by regulation of the Treg/Th17 and Th2/Th1 balances after trauma.

A review of the mechanisms of keratinocytes damage caused by Staphylococcus aureus infection in patients with atopic dermatitis
Xin Tian, Qiongxiao Huang, Jingyao Liang, Jianqin Wang, Jing Zhang, Yan Yang, Qianru Ye, Suling He, Junlong Li, Zhouwei Wu, Yumei Liu

Pages: 1163-1169 | First Published:29 September 2021

Graphical Abstract

Review of the mechanisms underlying the immune and inflammatory damage from keratinocytes caused by S. aureus; may help guide treatment options for patients with atopic dermatitis.

Open Access
Identification of HLA‐A2 restricted CD8+ T cell epitopes in SARS‐CoV‐2 structural proteins
Jieping Deng, Junping Pan, Minghui Qiu, Lipeng Mao, Zhigang Wang, Guodong Zhu, Lijuan Gao, Jun Su, Yutian Hu, Oscar Junhong Luo, Guobing Chen, Pengcheng Wang

Pages: 1171-1180 | First Published:07 July 2021

Graphical Abstract

Identifies CD8+ T cell epitopes in SARS-CoV-2 structural proteins, helping to further define specific immune responses that could aid in vaccine development for SARS-CoV-2.

Multi‐omics analysis of the expression and prognostic value of the butyrophilins in breast cancer
He Ren, Shuliang Li, Xin Liu, Wanjing Li, Jianlei Hao, Na Zhao

Pages: 1181-1195 | First Published:19 August 2021

Graphical Abstract

Exploring the biological roles of the butyrophilins gene family provides new insight into cancer pathogenesis and breast cancer prognosis.

Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL‐6 production
Cheng Zhong, Lixiang Wang, Shengzhao Hu, Chunliu Huang, Zijin Xia, Jing Liao, Wei Yi, Jun Chen

Pages: 1197-1208 | First Published:14 May 2021

Graphical Abstract

Poly(I:C) plus CD47/SIRPa blockade therapy appears to improve anti-tumor immunity through IL-6 and PI3K-depedent cytoskeleton organization; could be a potential novel strategy for combinational cancer immunotherapy of solid malignancies.


Stem cell‐like memory T cells: The generation and application
Yutong Wang, Feng Qiu, Yifan Xu, Xiaorui Hou, Zhili Zhang, Lei Huang, Huijun Wang, Hui Xing, Sha Wu

Pages: 1209-1223 | First Published:17 August 2021

Graphical Abstract

The induction and clinical application of stem like memory T cells suggest its promising protective and theraputic usage.

Virtual SLB Annual Meeting

Guest Editors: Ilhem Messaoudi, Louis Justement, Juhi Bagaitkar, Cynthia Leifer, Irving Coy Allen, Deborah A. Fraser


Free Access
Corticosteroid treatment in COVID‐19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation
Amanda N. Pinski, Tara L. Steffen, Michael Z. Zulu, Sarah L. George, Alexandria Dickson, Delia Tifrea, Kevin J. Maroney, Neil Tedeschi, Yun Zhang, Richard H. Scheuermann, Amelia K. Pinto, James D. Brien, Ilhem Messaoudi

Pages: 1225-1239 | First Published:03 November 2021

Graphical Abstract

Corticosteroids treatment significantly dampens the dysregulated inflammatory and apoptotic responses seen in acute severe COVID-19


Neutrophils vs. amoebas: Immunity against the protozoan parasite Entamoeba histolytica
Carlos Rosales

Pages: 1241-1252 | First Published:04 June 2021

Graphical Abstract

Reviews the role of neutrophils in preventing amoebiasis.

Virtual SLB Annual Meeting

Guest Editors: Ilhem Messaoudi, Louis Justement, Juhi Bagaitkar, Cynthia Leifer, Irving Coy Allen, Deborah A. Fraser


Dynamic changes in human single‐cell transcriptional signatures during fatal sepsis
Xinru Qiu, Jiang Li, Jeff Bonenfant, Lukasz Jaroszewski, Aarti Mittal, Walter Klein, Adam Godzik, Meera G. Nair

Pages: 1253-1268 | First Published:24 September 2021

Graphical Abstract

Single cell transcriptomics of peripheral blood mononuclear cells in surviving and fatal sepsis reveal inflammatory and metabolic pathways that change within hours of sepsis recognition.

Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?
Jian-Da Lin, P'ng Loke

Pages: 1269-1276 | First Published:01 September 2021

Graphical Abstract

Reviews helminth infection's impact on the immune system and the microbiota; provides mechanistic insight that may aid in finding new approaches for treating cardiovascular disease.


Free Access
Zhaoliang Su

Pages: 1277-1278 | First Published:29 November 2021

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