JLB TOC Vol 111 Issue 1

Cover Image Journal of Leukocyte Biology
Volume 111, Issue 1

Pages: 1-289

January 2022



Free Access
Issue Information

Pages: 1-5 | First Published:28 December 2021


Differential training of innate leukocytes getting compartmentalized
Shuo Geng, Liwu Li

Pages: 7-8 | First Published:12 October 2021

Graphical Abstract

Discussion on the discovery of compartmentalized innate immune training, and its relevance for the general context of innate immune memory dynamics.


Open Access
Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia
Anaísa V. Ferreira, Rienke F. Uijen, Ozlem Bulut, Marien I. de Jonge, Jorge Domínguez-Andrés, Mihai G. Netea

Pages: 9-17 | First Published:01 October 2021

Graphical Abstract

Splenectomy allows for a largely intact innate immune memory response, except for the reduction of trained immunity- induced neutrophilia.

SLB Member Issue – Extracellular Vesicles in Immunity

Guest Editors: Mallary Greenlee-Wacker, Laxmi Yeruva, Véronique Witko-Sarsat


Adipose‐derived stem cell‐derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622‐mediated transcription factor AR
Mengguo Guo, Dongpeng Li, Yawen Feng, Mu Li, Bo Yang

Pages: 19-32 | First Published:27 August 2021

Graphical Abstract

Adipose-derived stem cell-derived extracellular vesicles inhibited neuroblastoma (NB) cell growth by carrying LINC00622 into NB cells to inhibit transcription factor androgen receptor and to promote gamma-aminobutyric acid B-type receptor 1 expression.

Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function
Micah L. Willis, Cressida Mahung, Shannon M. Wallet, Alexandra Barnett, Bruce A. Cairns, Leon G. Coleman Jr., Robert Maile

Pages: 33-49 | First Published:03 August 2021

Graphical Abstract

Extracellular vesicles released into the plasma after severe burn injury transduce dysfunctional immune signaling in naive mice and macrophages similar to the clinical course after burn.


Role of extracellular vesicles in atherosclerosis: An update
Pierre-Michaël Coly, Chantal M. Boulanger

Pages: 51-62 | First Published:08 September 2021

Graphical Abstract

Review of the role of extracellular vesicles during the different phases of atherosclerotic lesion development that describes the need to standardize isolation and analysis procedures to fully realize their potential as biomarkers and therapeutics for cardiovascular diseases.

Free Access
Platelet extracellular vesicles in COVID‐19: Potential markers and makers
Florian Puhm, Louis Flamand, Eric Boilard

Pages: 63-74 | First Published:03 November 2021

Graphical Abstract

Review on platelet extracellular vesicles (pEVs); includes a special focus on pEV's potential as predictors of and contributors to COVID-19.

Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases
Mrigya Babuta, Gyongyi Szabo

Pages: 75-92 | First Published:10 November 2021

Graphical Abstract

Extracellular vesicle-associated miRNAs alter the immune response by inter-cellular and inter-organ communication and thereby contribute to the pathobiology of various liver diseases.

The emerging therapeutic potential of extracellular vesicles in trauma
Nijmeh Alsaadi, Amudan J. Srinivasan, Anupamaa Seshadri, Matthew Shiel, Matthew D. Neal, Melanie J. Scott

Pages: 93-111 | First Published:17 September 2021

Graphical Abstract

Review of current extracellular vesicle-based treatment modalities in hemostasis, inflammation, acute lung injury, traumatic brain injury, and spinal cord injury following trauma, and potential for the future.


More than neutrophils: Lin(+)Ly6G(+)IL‐5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes
Brian M. Jeong, Matthew T. Walker, Raul Rodriguez, Mackenzie E. Coden, Reina Nagasaka, Ton C. Doan, Yuliya Politanska, Hiam Abdala-Valencia, Sergejs Berdnikovs

Pages: 113-122 | First Published:15 April 2021

Graphical Abstract

Characterization of neutrophil-like Lin(+)Ly6G(+)IL-5Rα(+) population in normal murine bone marrow reveals its unexpected myeloid plasticity with substantial potential to differentiate to mature eosinophils and monocytes


Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen‐induced liver injury
Lindsey Devisscher, Sanne Van Campenhout, Sander Lefere, Sarah Raevens, Laurentijn Tilleman, Filip Van Nieuwerburgh, Hannelore P. Van Eeckhoutte, Anne Hoorens, Michael A. Lynes, Anja Geerts, Debby Laukens, Hans Van Vlierberghe

Pages: 123-133 | First Published:16 March 2021

Graphical Abstract

Anti-metallothionein antibody therapy reduces liver injury in experimental acetaminophen overdose.

Hspa8 and ICAM‐1 as damage‐induced mediators of γδ T cell activation
Margarete D. Johnson, Michel F. Otuki, Daniela A. Cabrini, Ross Rudolph, Deborah A. Witherden, Wendy L. Havran

Pages: 135-145 | First Published:13 April 2021

Graphical Abstract

Identifies two new molecules that are upregulated by keratinocytes in the wound environment and which induce activation of skin-resident gamma delta T cells.


Metabolic and functional impairment of CD8+ T cells from the lungs of influenza‐infected obese mice
William D. Green, Abrar E. Al-Shaer, Qing Shi, Kymberly M. Gowdy, Nancie J. MacIver, J. Justin Milner, Melinda A. Beck, Saame Raza Shaikh

Pages: 147-159 | First Published:13 April 2021

Graphical Abstract

Diet-induced obesity impairs the metabolism of pulmonary CD8+ T cells concomitant with differential gene transcription and reduced effector CD8+ T cells following primary influenza infection.


Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation
Christelle Piperoglou, Guillaume Larid, Blandine Vallentin, Laura Balligand, Adeline Crinier, Nathalie Banzet, Catherine Farnarier, Elena Gomez-Massa, Aranzazu Cruz Adalia, CRYOSTEM Consortium , Gérard Michel, Claire Galambrun, Vincent Barlogis, Eric Vivier, Frédéric Vély

Pages: 161-172 | First Published:13 April 2021

Graphical Abstract

Patients with graft-versus-host disease after hematopoietic stem cell transplantation showed slow recovery of circulating innate lymphoid cells and a reduced number of activated ILCP; this is consistent with a non-redundant role of this ILC subset in preventing this life-threatening disorder under lymphopenic conditions.


A review of signaling and transcriptional control in T follicular helper cell differentiation
Andrew P. Hart, Terri M. Laufer

Pages: 173-195 | First Published:18 April 2021

Graphical Abstract

Transcriptional regulation and epigenetic remodeling stabilize Tfh subset identity and require multiple APC-mediated stages of activation

Open Access
The regulatory role of insulin in energy metabolism and leukocyte functions
Walter David Cruz-Pineda, Isela Parra-Rojas, Hugo Alberto Rodríguez-Ruíz, Berenice Illades-Aguiar, Inés Matia-García, Olga Lilia Garibay-Cerdenares

Pages: 197-208 | First Published:16 March 2021

Graphical Abstract

Review on the role of insulin in metabolism and leukocyte function

Open Access
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease
E. Evonne Jean, Olivia Good, Juan M. Inclan Rico, Heather L. Rossi, De'Broski R. Herbert

Pages: 209-221 | First Published:15 April 2021

Graphical Abstract

Review of how neural afferents initiate immune responses via neuropeptides, and resolve inflammation and airway constriction via CGRP, NMB, VIP, and ARDB2 signaling.

K27‐linked noncanonic ubiquitination in immune regulation
Qingqing Zhou, Jun Zhang

Pages: 223-235 | First Published:15 April 2021

Graphical Abstract

Review shows how K27-linked ubiquitination regulates innate immunity and T cell signaling pathways.

Cellular immune responses in the pathophysiology of preeclampsia
Derek Miller, Kenichiro Motomura, Jose Galaz, Meyer Gershater, Eun D. Lee, Roberto Romero, Nardhy Gomez-Lopez

Pages: 237-260 | First Published:13 April 2021

Graphical Abstract

Innate and adaptive immune cell responses in women with preeclampsia


Open Access
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF induction
Xiaoling Qiang, Shu Zhu, Jianhua Li, Weiqiang Chen, Huan Yang, Ping Wang, Kevin J. Tracey, Haichao Wang

Pages: 261-267 | First Published:24 March 2021

Graphical Abstract

SARS-CoV-2 Spike Protein-reactive monoclonal antibodies specifically impaired the viral spike protein-induced GM-CSF secretion by human peripheral blood mononuclear cells.

Free Access
T cell counts and IL‐6 concentration in blood of North African COVID‐19 patients are two independent prognostic factors for severe disease and death
Brahim Belaid, Lydia Lamara Mahammad, Belgacem Mihi, Sarah Yasmine Rahali, Asma Djidjeli, Zineb Larab, Lilya Berkani, Ismahane Berkane, Wafa Sayah, Fatma Merah, Nouzha Zhor Lazli, Lylia Kheddouci, Ahmed Kadi, Mourad Ouali, Rachida Khellafi, Dalila Mekideche, Assia Kheliouen, Soraya Ayoub, Réda Malek Hamidi, Fawzi Derrar, Merzak Gharnaout, Ines Allam, Réda Djidjik

Pages: 269-281 | First Published:02 February 2021

Graphical Abstract

COVID-19 patients with poor prognosis exhibited a significant depletion of lymphocyte-subset counts, with remarkably increasing concentrations of IL6 and IL10.

Free Access
TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID‐19 patients
Jorn L.J.C. Assmann, P. Martijn Kolijn, Benjamin Schrijver, Adriaan J. van Gammeren, Daan W. Loth, Ton A.A.M. Ermens, Willem A. Dik, Vincent H.J. van der Velden, Anton W. Langerak

Pages: 283-289 | First Published:13 April 2021

Graphical Abstract

The T cell receptor beta chain (TRB) repertoire of hospitalized COVID-19 patients revealed that TRB sequences targeting nonstructural proteins of SARS-CoV-2 may negatively affect disease severity.