Free Access

Issue Information

Pages: 291-295 | First Published:28 January 2022

Open Access

T cells and monocytes: A dangerous liaison in adenosine deaminase 2 deficiency

Pages: 297-299 | First Published:28 January 2022

Single‐cell profiling of T lymphocytes in deficiency of adenosine deaminase 2

Pages: 301-312 | First Published:03 November 2021

Graphical Abstract

T lymphocytes are activated and actively involved in DADA2 pathogenesis; and ligand-receptor crosstalk with monocytes likely leads to up-regulation of STAT1 and subsequently augmented responses of cells to IFN upon stimulation.

Identification of altered cell signaling pathways using proteomic profiling in stable and progressive chronic lymphocytic leukemia

Pages: 313-325 | First Published:20 July 2021

Graphical Abstract

Proteomic profiles at the early stage of CLL can discriminate progressive from stable disease and RNA splicing and cell cycle dysregulation underlies CLL evolution; opening new perspectives on potential biomarkers and therapy.

Guest Editors: Rebecca Ambrose, Nicole Campbell, Joshua Hayward, Thomas Shultz, Carmen Taveras, Rebecca Smith, and Wilson Wong

REVIEWS

The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms

Divya Ramnath, Kaustav Das Gupta, Yizhuo Wang, Rishika Abrol, James E. B. Curson, Junxian Lim, Robert C. Reid, Ashley Mansell, Antje Blumenthal, Denuja Karunakaran, David P. Fairlie, Matthew J. Sweet

Pages: 327-336 | First Published:23 November 2021

Graphical Abstract

Demonstration that TLR-inducible Hdac7 enzymatic activity is required for inducible cytokine production in murine macrophages, whereas it instructs inducible glycolysis independently of enzyme activity.

Immunoregulation by type I interferons in the peritoneal cavity

Jasmine J. M. Chuah, Paul J. Hertzog, Nicole K. Campbell

Pages: 337-353 | First Published:06 October 2021

Graphical Abstract

Review of how peritoneal immune cells and type I interferons protect against or promote disease in the peritoneal cavity.

Free Access

T follicular helper cells in the humoral immune response to SARS‐CoV‐2 infection and vaccination

Marios Koutsakos, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

Pages: 355-365 | First Published:03 November 2021

Graphical Abstract

Review on the analysis of TFH cells during COVID-19 infection and vaccination and the role of these cells as biomarkers of neutralising antibody development.

Open Access

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Pages: 367-377 | First Published:22 April 2021

Graphical Abstract

First study to report CD200R1L protein expression in humans; CD200R1L induces production of reactive oxygen species and IL-8.

ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection

Pages: 379-389 | First Published:18 April 2021

Graphical Abstract

The ER stress protein PERK induces an altered innate immune phenotype in DC that promotes a pathogenic response during RSV infection.

MiR‐155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis

Pages: 391-400 | First Published:11 June 2021

Graphical Abstract

MiR-155 regulates pulmonary formation of NETs in abdominal sepsis via PAD4 upregulation and histone 3 citrullination; miR-155 could be a useful target to reduce pulmonary damage in abdominal sepsis.

Sustained IL‐4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848

Pages: 401-413 | First Published:19 May 2021

Graphical Abstract

Prolonged priming with IL-4 alone promotes an antiviral response in macrophages, and augments their pro-inflammatory cytokine production after R848 treatment.

B10 cells decrease fibrosis progression following cardiac injury partially by IL‐10 production and regulating hyaluronan secretion

Pages: 415-425 | First Published:19 May 2021

Graphical Abstract

B10 cells benefit cardiac scar-free repair following cardiac injury partially by IL-10 production and regulating hyaluronan secretion.

A novel clinically relevant graft‐versus‐leukemia model in humanized mice

Pages: 427-437 | First Published:31 May 2021

Graphical Abstract

A novel humanized graft-vs-leukemia model was established by grafting human donor hematopoietic stem cells and patient-derived acute myeloid leukemia cells into NSG mice.

Safety analysis of ex vivo‐expanded canine natural killer cells in a xenogeneic mouse model of graft‐versus‐host disease

Pages: 439-450 | First Published:22 April 2021

Graphical Abstract

Expanded canine NK cells do not cause GVHD in a xenogeneic GVHD model and can be investigated for cancer immunotherapy without removing the CD3⁺TCR^- cells in dogs.

Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Pages: 451-467 | First Published:22 April 2021

Graphical Abstract

Review on the involvement of regulatory lymphocytes, including regulatory B and T cells, in periodontitis and related systemic inflammatory diseases.

Immunopathogenesis of oral submucous fibrosis by chewing the areca nut

Pages: 469-476 | First Published:14 June 2021

Graphical Abstract

Shows the importance of immune regulation in oral submucous fibrosis (OSF); examines T lymphocytes, B lymphocytes, dendritic cells, mast cells, and related immune complexes and their roles in the pathogenesis and treatment of OSF.

Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity

Pages: 477-487 | First Published:22 April 2021

Graphical Abstract

Review on how lymphocyte sense the spatial origin and age of antibodies in immune complexes through FCRL3, FCRL4, and FCRL5, informing and driving their functional responses.

Free Access

Emergence of immunosuppressive LOX‐1+ PMN‐MDSC in septic shock and severe COVID‐19 patients with acute respiratory distress syndrome

Pages: 489-496 | First Published:28 April 2021

Graphical Abstract

COVID-19 and septic shock induce emergence of LOX-1+ MDSC

Free Access

Inflammasome regulation in driving COVID‐19 severity in humans and immune tolerance in bats

Pages: 497-508 | First Published:31 May 2021

Graphical Abstract

Human SARS-CoV-2 infection-induced inflammasome activation is associated with COVID-19 severity, whereas bats, which host pathogenic CoVs, show dampened inflammasome activation and immune tolerance to viral infections.