| JLB Vol 112, Issue 2 |
ISSUE INFORMATION  Free Access
Issue InformationPages: 213-217 | First Published: 23 July 2022 EDITORIAL T‐Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction Austin W Kerr, Philip A Efron, Shawn D Larson, Jaimar C Rincon
Pages: 219-220 | First Published: 28 April 2022  Graphical Abstract Discussion on how T-cell activation via TCR pathway impacts LPS-mediated inflammation and organ dysfunction. SPOTLIGHT ON LEADING EDGE RESEARCH T cell activation and IFNγ modulate organ dysfunction in LPS‐mediated inflammation Matthew D. Taylor, Tiago D. Fernandes, Omar Yaipen, Cassidy E. Higgins, Christine A. Capone, Daniel E. Leisman, Ana Nedeljkovic-Kurepa, Mabel N. Abraham, Mariana R. Brewer, Clifford S. Deutschman
Pages: 221-232 | First Published: 09 February 2022  Graphical Abstract T cell activation reduces the lethal dose of lipopolysaccharide 10-fold with major alterations in the immunological responses, while causing similar clinical outcomes. CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING Effects of TNF‐α deletion on iNKT cell development, activation, and maturation in the steady‐state and chronic alcohol‐consuming mice Hui Zhang, Faya Zhang, Samantha Modrak
Pages: 233-241 | First Published: 12 November 2021  Graphical Abstract TNF-a plays an important role in iNKT cell development, activation and maturation, and chronic alcohol consumption enhances iNKT cell activation and maturation through TNF-a. RECEPTORS, SIGNAL TRANSDUCTION AND GENES SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu
Pages: 243-255 | First Published: 06 January 2022  Graphical Abstract SUZ12 overexpression in abnormal clones in PNH patients regulates cell proliferation, apoptosis and the cell cycle by affecting the trimethylation level of H3K27 , thus conferring proliferation advantages to abnormal PNH clones, which then participate in the pathogenesis of PNH. INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES IRF3 inhibits IFN‐γ‐mediated restriction of intracellular pathogens in macrophages independently of IFNAR Karolina Maciag, Raktima Raychowdhury, Karen Smith, Alexis M. Schneider, Jörn Coers, Maxwell R. Mumbach, Schraga Schwartz, Nir Hacohen
Pages: 257-271 | First Published: 26 November 2021  Graphical Abstract IRF3 modulates multiple responses of IFNγ-primed macrophages to intracellular bacteria, including production of nitric oxide; meanwhile, IFNγ reciprocally inhibits IRF3, contributing to immune homeostasis.  Open Access
The anti‐inflammatory peptide Catestatin blocks chemotaxis Elke M. Muntjewerff, Kristel Parv, Sushil K. Mahata, N. Koen van Riessen, Mia Phillipson, Gustaf Christoffersson, Geert van den Bogaart
Pages: 273-278 | First Published: 22 December 2021  Graphical Abstract Catestatin blocks monocyte and granulocyte migration toward inflammatory chemokines. Open Access
Immune modulatory effects of progesterone on oxLDL‐induced trained immunity in monocytes Laszlo A. Groh, Dagmar E. Verel, Charlotte D.C.C van der Heijden, Vasiliki Matzaraki, Simone J.C.F.M. Moorlag, L. Charlotte de Bree, Valerie A.C.M. Koeken, Vera P. Mourits, Samuel T. Keating, Jelmer H. van Puffelen, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Pages: 279-288 | First Published: 17 January 2022  Graphical Abstract Cytokine production by oxLDL-induced trained immunity is inhibited by the steroid hormone progesterone. HOST DEFENSE AND PATHOPHYSIOLOGY Open Access
Crosstalk between R848 and abortive HIV‐1 RNA‐induced signaling enhances antiviral immunity Melissa Stunnenberg, John L. van Hamme, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B.H. Geijtenbeek
Pages: 289-298 | First Published: 04 January 2022  Graphical Abstract Abortive HIV-1 RNA modulates TLR7/8-dependent signaling to induce effective antiviral innate and adaptive immunity in human dendritic cells. SYSTEM BIOLOGY AND IMMUNOGENETICS Open Access
Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy Ruolan You, Diyu Hou, Bin Wang, Jingru Liu, Xiaoting Wang, Qirong Xiao, Zhipeng Pan, Dongliang Li, Xiaoming Feng, Lixia Kang, Ping Chen, Huifang Huang
Pages: 299-311 | First Published: 20 December 2021  Graphical Abstract Stromal contact renders AML cells chemoresistance by promoting AML cells' OXPHOS activity and OXPHOS's mechanism of action involves AMPK-mTORC1 pathway. REVIEW Open Access
Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine Qian Cao, Randall Tyler Mertens, Kisha Nandini Sivanathan, Xuechun Cai, Peng Xiao
Pages: 313-331 | First Published: 20 May 2022  Graphical Abstract This review focuses on how macrophages regulate intestine inflammation through cross-talking with epithelial cells and mesenchymal cells in the gut. COVID-19 INITIATIVE Free Access
Circulating B10 regulatory cells are decreased in severe and critical COVID‐19 Rodrigo Cervantes-Díaz, Víctor A. Sosa-Hernández, Sandra Romero-Ramírez, Jiram Torres-Ruiz, Alfredo Pérez-Fragoso, David E. Meza-Sánchez, Diana Gómez-Martín, José L. Maravillas-Montero
Pages: 333-337 | First Published: 24 February 2022  Graphical Abstract The B regulatory subset B10 (CD24hiCD27+IL-10+) was found depleted during severe/critical COVID-19 acute disease, negatively correlating with inflammatory parameters. Open Access
Cross‐reactive cellular, but not humoral, immunity is detected between OC43 and SARS‐CoV‐2 NPs in people not infected with SARS‐CoV‐2: Possible role of cTFH cells Álvaro Fernando García-Jiménez, Yaiza Cáceres-Martell, Daniel Fernández-Soto, Pedro Martínez Fleta, José M. Casasnovas, Francisco Sánchez-Madrid, José Miguel Rodríguez Frade, Mar Valés-Gómez, Hugh T. Reyburn
Pages: 339-346 | First Published: 05 April 2022  Graphical Abstract Deficiencies in T follicular cell responses may underlie the lack of cross-reactive antibodies between COVID-19 and seasonal coronaviruses. LETTER TO THE EDITOR Joost J. Oppenheim: 1934–2022 Sharon M. Wahl, Howard A. Young
Pages: 347-351 | First Published: 23 June 2022  Graphical Abstract - ERRATUM Free Access
ERRATUMPages: 353 | First Published: 25 May 2022
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