Open Access
Metabolic impact of adipose tissue macrophages in the early postnatal life
Tamás Röszer
Version of Record online: 28 July 2022
Graphical Abstract
Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long-term impact on obesity status.
The extracellular sialidase NEU3 primes neutrophils
Sara A. Kirolos, Darrell Pilling, Richard H. Gomer
Version of Record online: 28 July 2022
Graphical Abstract
The extracellular sialidase enzyme NEU3 is upregulated in fibrotic lesions, and here we show that extracellular recombinant human NEU3 partially desialylates and primes human neutrophils.
Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado
Version of Record online: 28 July 2022
Graphical Abstract
Review of recent advances in inborn errors of immunity predisposing to hemophagocytic lymphohistiocytosis.
Open Access
Sepsis, pyruvate, and mitochondria energy supply chain shortage
Charles E. McCall, Xuewei Zhu, Manal Zabalawi, David Long, Matthew A. Quinn, Barbara K. Yoza, Peter W. Stacpoole, Vidula Vachharajani
Version of Record online: 22 July 2022
Graphical Abstract
This review summarizes our research identifying mitochondrial pyruvate oxidative metabolism and its coupling to tricarboxylic (TCA) cycle resistance and disease tolerance energetics as pathway to sepsis survival.
Achieving intracellular cytokine staining assay concordance on two continents to assess HIV vaccine‐induced T‐cell responses
One B. Dintwe, Stephen C. De Rosa, Yunda Huang, Britta S. Flach, Bryce Manso, Don Carter, Faatima Laher Omar, Katharine V. Schwedhelm, Chenchen Yu, Huiyin Lu, Daryl Morris, Jia Jin Kee, Valentin Voillet, Michael Stirewalt, John Hural, Zoe Moodie, Nicole Frahm, Kristen W. Cohen, M. Juliana McElrath, Erica Andersen-Nissen
Version of Record online: 22 July 2022
Graphical Abstract
Outcomes of quality control for achieving inter-lab concordance of the ICS assay.
Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype
Carolina G. Dolislager, Sean M. Callahan, Dallas R. Donohoe, Jeremiah G. Johnson
Version of Record online: 22 July 2022
Graphical Abstract
Campylobacter jejuni infection of neutrophils results in differentiation of a subtype which activates HIF-1 and NF-κB in colonocytes and decreases TCRζ in T cells.
Free Access
Single‐cell immune profiling reveals long‐term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID‐19 hospitalization
William J. Pandori, Lindsey E. Padgett, Ahmad Alimadadi, Norma A. Gutierrez, Daniel J. Araujo, Christine J. Huh, Claire E. Olingy, Huy Q. Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J. Chee, Christian H. Ottensmeier, Catherine C. Hedrick
Version of Record online: 22 July 2022
Graphical Abstract
SARS-CoV-2 infection induces long-lasting changes in the myeloid cell compartment, and novel monocyte subsets, distinguished by expression of CD9 and Slan, correlate with COVID-19 severity.
Open Access
Physiologic roles of P2 receptors in leukocytes
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, André Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristóvão de Albuquerque, Wilson Savino, Robson Coutinho-Silva, Pedro Muanis Persechini, Luiz Anastacio Alves
Version of Record online: 15 July 2022
Graphical Abstract
Review of how purinergic P2 receptors expression and activation in leukocytes control the development of inflammation, infectious diseases, and pain.
IL‐17A aggravates asthma‐induced intestinal immune injury by promoting neutrophil trafficking
Yanfei Hong, Zhulang Chu, Jingwei Kong, Qiuyi Li, Na Li, Liting Liu, Tong Wu, Jiajing Liu, Dongyu Ge, Jie Li, Guiying Peng
Version of Record online: 11 July 2022
Graphical Abstract
IL-17A aggravates asthma-induced intestinal immune injury by promoting neutrophil trafficking, which facilitates the explorations for new potential biomarkers for the treatment of asthma.
Open Access
Analysis of potential biomarkers of response to IL‐12 therapy
Emily Schwarz, William E. Carson III
Version of Record online: 04 July 2022
Graphical Abstract
Review of potential correlates of beneficial patient response to IL-12 therapy in the treatment of cancer.