JLB Early View - August '22

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue
Open Access

ARTICLES

Metabolic impact of adipose tissue macrophages in the early postnatal life
Tamás Röszer

Version of Record online: 28 July 2022

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Graphical Abstract

Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long-term impact on obesity status.

ARTICLES

The extracellular sialidase NEU3 primes neutrophils
Sara A. Kirolos, Darrell Pilling, Richard H. Gomer

Version of Record online: 28 July 2022

Description unavailable
Graphical Abstract

The extracellular sialidase enzyme NEU3 is upregulated in fibrotic lesions, and here we show that extracellular recombinant human NEU3 partially desialylates and primes human neutrophils.

REVIEWS

Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado

Version of Record online: 28 July 2022

Description unavailable
Graphical Abstract

Review of recent advances in inborn errors of immunity predisposing to hemophagocytic lymphohistiocytosis.

Open Access

ARTICLES

Sepsis, pyruvate, and mitochondria energy supply chain shortage
Charles E. McCall, Xuewei Zhu, Manal Zabalawi, David Long, Matthew A. Quinn, Barbara K. Yoza, Peter W. Stacpoole, Vidula Vachharajani

Version of Record online: 22 July 2022

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Graphical Abstract

This review summarizes our research identifying mitochondrial pyruvate oxidative metabolism and its coupling to tricarboxylic (TCA) cycle resistance and disease tolerance energetics as pathway to sepsis survival.

ARTICLES

Achieving intracellular cytokine staining assay concordance on two continents to assess HIV vaccine‐induced T‐cell responses
One B. Dintwe, Stephen C. De Rosa, Yunda Huang, Britta S. Flach, Bryce Manso, Don Carter, Faatima Laher Omar, Katharine V. Schwedhelm, Chenchen Yu, Huiyin Lu, Daryl Morris, Jia Jin Kee, Valentin Voillet, Michael Stirewalt, John Hural, Zoe Moodie, Nicole Frahm, Kristen W. Cohen, M. Juliana McElrath, Erica Andersen-Nissen

Version of Record online: 22 July 2022

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Graphical Abstract

Outcomes of quality control for achieving inter-lab concordance of the ICS assay.

ARTICLES

Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype
Carolina G. Dolislager, Sean M. Callahan, Dallas R. Donohoe, Jeremiah G. Johnson

Version of Record online: 22 July 2022

Description unavailable
Graphical Abstract

Campylobacter jejuni infection of neutrophils results in differentiation of a subtype which activates HIF-1 and NF-κB in colonocytes and decreases TCRζ in T cells.

Free Access

COVID-19 SPECIAL SECTION

Single‐cell immune profiling reveals long‐term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID‐19 hospitalization
William J. Pandori, Lindsey E. Padgett, Ahmad Alimadadi, Norma A. Gutierrez, Daniel J. Araujo, Christine J. Huh, Claire E. Olingy, Huy Q. Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J. Chee, Christian H. Ottensmeier, Catherine C. Hedrick

Version of Record online: 22 July 2022

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Graphical Abstract

SARS-CoV-2 infection induces long-lasting changes in the myeloid cell compartment, and novel monocyte subsets, distinguished by expression of CD9 and Slan, correlate with COVID-19 severity.

Open Access

REVIEW

Physiologic roles of P2 receptors in leukocytes
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, André Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristóvão de Albuquerque, Wilson Savino, Robson Coutinho-Silva, Pedro Muanis Persechini, Luiz Anastacio Alves

Version of Record online: 15 July 2022

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Graphical Abstract

Review of how purinergic P2 receptors expression and activation in leukocytes control the development of inflammation, infectious diseases, and pain.

INFLAMMATION, EXTRACELLULAR MEDIATORS, AND EFFECTOR MOLECULES

IL‐17A aggravates asthma‐induced intestinal immune injury by promoting neutrophil trafficking
Yanfei Hong, Zhulang Chu, Jingwei Kong, Qiuyi Li, Na Li, Liting Liu, Tong Wu, Jiajing Liu, Dongyu Ge, Jie Li, Guiying Peng

Version of Record online: 11 July 2022

Description unavailable
Graphical Abstract

IL-17A aggravates asthma-induced intestinal immune injury by promoting neutrophil trafficking, which facilitates the explorations for new potential biomarkers for the treatment of asthma.

Open Access

REVIEW

Analysis of potential biomarkers of response to IL‐12 therapy
Emily Schwarz, William E. Carson III

Version of Record online: 04 July 2022

Description unavailable
Graphical Abstract

Review of potential correlates of beneficial patient response to IL-12 therapy in the treatment of cancer.