Review of morphologies and mechanical properties of leukocyte nuclei, their regulation by nuclear envelope proteins, and their many roles in leukocyte migration.

R4 RGS proteins exhibit profound impact on the trafficking of blood stem cells and represent promising drug targets for enhancing clinical stem cell transplantation.

Review on the structures, physiological functions, inhibitors of LUBAC, and related diseases caused by LUBAC aberration, providing comprehensively insight into LUBAC research.

The potential of immunotherapy against mesothelin in the treatment of acute myeloid leukemia.

Interleukin-15 agonists offer a new therapeutic option in the future direction of cancer immunotherapy.

Bile acid (BA) synthesis and cholesterol clearance pathway. Regulation of BA synthesis by feedback mechanism and BA transport through enterohepatic circulation. In the liver, cholesterol is metabolized to primary BAs (CA, CDCA) via primary pathway and alternative pathway, and conjugated with glycine or taurine, converted to TCA, GCA, GCDCA, and TCDCA. Primary BAs are transported to intestine via biliary excretion, and converted to secondary BAs (DCA, UDCA, LCA) by gut commensal bacteria, and conjugated with glycine or taurine, converted to GDCA, TUDCA, GUDCA, and GLCA. As the most common secondary BA, LCA is also oxidized to 3-oxo-LCA, or reabsorbed to the hepatocytes and converted into LCA-3-S in the liver. After conjugation, BAs are again excreted into the bile duct, completing the enterohepatic circulation. In the study, we explored that the sulfate of LCA, LCA-3-S, could bind to RORγt resulting in selectively inhibitory effect on Th17 cell differentiation, which might contribute to the prevention of cholestatic liver diseases.

Data to support: (i) c-Rel-dependent monocytes (rMos) are a new subset of myeloid suppressor cells with a unique set of markers; and (ii) the differentiation of rMos is specified by a lineage-specific transcriptional complex called c-Rel enhanceosome.

HBP, which has the functions of inflammatory and fibrotic induction, as well as the advantage of pre-sythesis for faster release, is an important predictor of the risk of acute exacerbation of ILD.

Acteoside promotes IL-10-producing capacity of B cells in a TLR4/PI3K dependent manner, and thus restores regulatory B cell function during autoimmune progression.

Development of a novel prognostic biomarker for LGG that may support evauation of immunotherapy strategies in brain cancer.

DLL3-CAR NK-92 cells showed significant anti-tumor effect on small cell lung cancer both in vitro and in vivo.

Tumor-intrinsic CD21 impairs the target cell recognition and the cytotoxicity of the CD19-CAR-T cells.

Disulfiram eradicates T-cell malignancies by targeting the NPL4-mediated ubiquitin-proteasome pathway, and NPL4, ANAPC1, and PSMD2 might be potential biomarkers for risk stratification.

A trajectory analysis of circulating ILCs and adaptive T cell lymphocytes subtypes in patients spanning a cascade of gastric lesions.