JLB Vol 112 Issue 4 TOC

Cover Image Journal of Leukocyte Biology
Volume 112, Issue 4
Focus Issue: Targeted Science — Special Focus Issue

Pages: 577-940

October 2022

 

ISSUE INFORMATION

Free Access
Issue Information

Pages: 577-583 | First Published: 30 September 2022

LETTER TO THE EDITOR

Neutrophil serine proteases in vitro: How much and why?
Eric K. Patterson, Douglas D. Fraser, Gediminas Cepinskas

Pages: 585-586 | First Published: 08 September 2022

EDITORIAL

Open Access
Scylla, Charybdis, and navigating antimicrobial action in the neutrophil phagosome
William M. Nauseef

Pages: 587-589 | First Published: 04 August 2022

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Graphical Abstract

How the collaborative efforts of granule contents and locally generated oxidants are countered by microbial actions to survive.

SPOTLIGHT ON LEADING EDGE RESEARCH

Open Access
Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes
Louisa V Ashby, Reuben Springer, Vu Van Loi, Haike Antelmann, Mark B Hampton, Anthony J Kettle, Nina Dickerhof

Pages: 591-605 | First Published: 27 May 2022

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Graphical Abstract

Bacterial bacillithiol was oxidized during phagocytosis but provided minimal protection against the neutrophil's killing mechanisms.

REVIEW

Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado

Pages: 607-615 | First Published: 28 July 2022

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Graphical Abstract

Review of recent advances in inborn errors of immunity predisposing to hemophagocytic lymphohistiocytosis.

CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING

Fatty acids secreted from head and neck cancer induce M2‐like Macrophages
Marwah M Albakri, Stanley Ching-Cheng Huang, Hammad N Tashkandi, Scott F Sieg

Pages: 617-628 | First Published: 25 February 2022

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Graphical Abstract

Fatty Acids from head and neck tumor cell lines mediate maturation of macrophages into cells with a limited pro-inflammatory phenotype.

Intrathymic SIRPa cDC subsets organization in normal and stress conditions reveal another level of cDCs heterogeneity
Victoria Michaels Lopez, Agnès Legrand, Emmanuel Tejerina, Jérome Megret, Chantal Bordin, Véronique Quellec, Sophie Ezine

Pages: 629-639 | First Published: 27 February 2022

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Graphical Abstract

Thymic SIRPa cDC subsets ontogeny and their interplays contribute to a suitable environment for T cell development

ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment
Spyridoula Tsiomita, Effrosyni Maria Liveri, Panagiota Vardaka, Angeliki Vogiatzi, Argyris Skiadaresis, George Saridis, Ioannis Tsigkas, Theologos M. Michaelidis, George Mavrothalassitis, George Thyphronitis

Pages: 641-657 | First Published: 08 March 2022

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Graphical Abstract

Erf transcriptional factor is a positive regulator of thymocyte maturation towards CD4 and CD8 commitment while negatively regulates γδ generation.

Open Access
The SC cell line as an in vitro model of human monocytes
Amira Duweb, Ann-Kathrin Gaiser, Isabel Stiltz, Menna El Gaafary, Thomas Simmet, Tatiana Syrovets

Pages: 659-668 | First Published: 31 March 2022

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Graphical Abstract

Polarized SC-derived macrophages may with some restrictions serve as a model for M1 but not for M2 macrophages.

RECEPTORS, SIGNAL TRANSDUCTION AND GENES

Gab2 promotes acute myeloid leukemia growth and migration through the SHP2‐Erk‐CREB signaling pathway
Rui Gong, Haoying Li, Yaqi Liu, Yanyan Wang, Lu Ge, Liuzhi Shi, Guang Wu, Jianxin Lyu, Haihua Gu, Licai He

Pages: 669-677 | First Published: 24 March 2022

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Graphical Abstract

Data to support model that Gab2 promotes AML progression through the SHP2-Erk-CREB pathway.

INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES

Open Access
Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1
Kedeye Tuerxun, Kristine Midtbö, Eva Särndahl, Egor Vorontsov, Roger Karlsson, Alexander Persson, Robert Kruse, Daniel Eklund, the X-HiDE Consortium

Pages: 679-692 | First Published: 13 March 2022

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Graphical Abstract

Differential cytokine response in endotoxin induced M-MDSC-like cells and their associated regulators.

Erythrocyte‐derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4–MyD88–NF‐κB–MAPK pathway
Yuhan Gao, Haiqiang Jin, Hui Tan, Xiaodong Cai, Yongan Sun

Pages: 693-706 | First Published: 12 April 2022

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Graphical Abstract

EVs aggravate inflammation by promoting the proinflammatory macrophage phenotype with upregulation of NF-κB and MAPK activity to favor macrophage cytokine production.

Neutrophil‐derived extracellular vesicles promote feed‐forward inflammasome signaling in cystic fibrosis airways
Osric A. Forrest, Brian Dobosh, Sarah A. Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A. Alvarez, Milton R. Brown, Vin Tangpricha, Rabindra Tirouvanziam

Pages: 707-716 | First Published: 16 February 2022

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Graphical Abstract

Blood neutrophils are reprogrammed upon entry into cystic fibrosis airways, releasing extracellular vesicles that can readily activate inflammasome signaling in naïve neutrophils and epithelial cells.

HOST DEFENSE AND PATHOPHYSIOLOGY

Human mucosal Vα7.2+CD161hi T cell distribution at physiologic state and in Helicobacter pylori infection
Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael N.T. Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J. Corbett, Rangsima Reantragoon

Pages: 717-732 | First Published: 15 June 2022

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Graphical Abstract

Study of human Vα7.2+CD161hi T cell distribution in peripheral blood and different sites of gastrointestinal tract, its TCR characteristics and response to Helicobacter pylori infection

Open Access
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection
Livio Azzoni, Leila B. Giron, Surya Vadrevu, Ling Zhao, Linden Lalley-Chareczko, Emily Hiserodt, Matthew Fair, Kenneth Lynn, Stacey Trooskin, Karam Mounzer, Mohamed Abdel-Mohsen, Luis J. Montaner

Pages: 733-744 | First Published: 02 August 2022

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Graphical Abstract

Long-term exposure to methadone may sustain immune activation and inflammation in ART-treated HIV-infected individuals, impairing their immune reconstitution outcomes.

TRANSLATIONAL AND CLINICAL IMMUNOLOGY

Landscape of T Cells in NK‐AML(M4/M5) Revealed by Single‐Cell Sequencing
Wenqi Wu, Xiaolin Liang, Huiqun Li, Xiaoke Huang, Chengyao Wan, Qiongni Xie, Zhenfang Liu

Pages: 745-758 | First Published: 08 March 2022

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Graphical Abstract

Analysis of infiltrating T cells from NK-AML (M4/M5) patients using single-cell sequencing reveals distinct clusters and clonal expansion of immune T cells.

TECHNICAL ADVANCE

Robust engraftment of fetal nonhuman primate CD34‐positive cells in immune‐deficient mice
Christopher J. Little, William J. Haynes, Liupei Huang, Cross M. Daffada, Bryce K. Wolfe, Elizabeth Perrin, John A. Simpson, Jenna A. Kropp Schmidt, Hayly M. Hinkle, Logan T. Keding, Ryan T. Behrens, David T. Evans, Dixon B. Kaufman, James A. Thomson, Thaddeus G. Golos, Matthew E. Brown

Pages: 759-769 | First Published: 30 March 2022

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Graphical Abstract

Engraftment of rhesus macaque hematopoietic tissues in immune-deficient mice yields a robust BLT/NeoThy-type primatized mouse model for studying non-human primate hematopoiesis and immune function in vivo.

Meeting: Targeted Science Issue - The 7th Macau Symposium on Biomedical Sciences and the South China Symposium on Frontiers in Immunology and Disease

Guest Editors: Jiahong Lu, Huanhuan He, Qi Zhao, and Xiang Lin

REVIEWS

Roles of the nucleus in leukocyte migration
Yutao Li, Mengqi Chen, Wakam Chang

Pages: 771-783 | First Published: 02 August 2022

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Graphical Abstract

Review of morphologies and mechanical properties of leukocyte nuclei, their regulation by nuclear envelope proteins, and their many roles in leukocyte migration.

R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking
Kathy Yuen Yee Chan, Po Yee Chung, Chi Zhang, Ellen Ngar Yun Poon, Alex Wing Kwan Leung, Kam Tong Leung

Pages: 785-797 | First Published: 13 June 2022

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Graphical Abstract

R4 RGS proteins exhibit profound impact on the trafficking of blood stem cells and represent promising drug targets for enhancing clinical stem cell transplantation.

Structures, functions, and inhibitors of LUBAC and its related diseases
Shuo Ning, Lingling Luo, Beiming Yu, Dina Mai, Feng Wang

Pages: 799-811 | First Published: 09 March 2022

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Graphical Abstract

Review on the structures, physiological functions, inhibitors of LUBAC, and related diseases caused by LUBAC aberration, providing comprehensively insight into LUBAC research.

Immunotherapy targeting mesothelin in acute myeloid leukemia
Qingguang Wang, Rui Gong

Pages: 813-821 | First Published: 10 August 2022

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Graphical Abstract

The potential of immunotherapy against mesothelin in the treatment of acute myeloid leukemia.

2022 update on the scientific premise and clinical trials for IL‐15 agonists as cancer immunotherapy
Yingjun Peng, Shengyu Fu, Qi Zhao

Pages: 823-834 | First Published: 26 May 2022

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Graphical Abstract

Interleukin-15 agonists offer a new therapeutic option in the future direction of cancer immunotherapy.

PRIMARY RESEARCH

Synthesis and identification of lithocholic acid 3‐sulfate as RORγt ligand to inhibit Th17 cell differentiation
Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Pages: 835-843 | First Published: 21 February 2022

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Graphical Abstract

Bile acid (BA) synthesis and cholesterol clearance pathway. Regulation of BA synthesis by feedback mechanism and BA transport through enterohepatic circulation. In the liver, cholesterol is metabolized to primary BAs (CA, CDCA) via primary pathway and alternative pathway, and conjugated with glycine or taurine, converted to TCA, GCA, GCDCA, and TCDCA. Primary BAs are transported to intestine via biliary excretion, and converted to secondary BAs (DCA, UDCA, LCA) by gut commensal bacteria, and conjugated with glycine or taurine, converted to GDCA, TUDCA, GUDCA, and GLCA. As the most common secondary BA, LCA is also oxidized to 3-oxo-LCA, or reabsorbed to the hepatocytes and converted into LCA-3-S in the liver. After conjugation, BAs are again excreted into the bile duct, completing the enterohepatic circulation. In the study, we explored that the sulfate of LCA, LCA-3-S, could bind to RORγt resulting in selectively inhibitory effect on Th17 cell differentiation, which might contribute to the prevention of cholestatic liver diseases.

c‐Rel‐dependent monocytes are potent immune suppressor cells in cancer
Ting Li, Mayassa J. Bou-Dargham, Norman Fultang, Xinyuan Li, Warren S. Pear, Honghong Sun, Youhai H. Chen

Pages: 845-859 | First Published: 13 June 2022

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Graphical Abstract

Data to support: (i) c-Rel-dependent monocytes (rMos) are a new subset of myeloid suppressor cells with a unique set of markers; and (ii) the differentiation of rMos is specified by a lineage-specific transcriptional complex called c-Rel enhanceosome.

Clinical utility of heparin‐binding protein as an acute‐phase inflammatory marker in interstitial lung disease
Mingshan Xue, Teng Zhang, Runpei Lin, Yifeng Zeng, Zhangkai Jason Cheng, Ning Li, Peiyan Zheng, Huimin Huang, Xiaohua Douglas Zhang, Hongman Wang, Baoqing Sun

Pages: 861-873 | First Published: 14 February 2022

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Graphical Abstract

HBP, which has the functions of inflammatory and fibrotic induction, as well as the advantage of pre-sythesis for faster release, is an important predictor of the risk of acute exacerbation of ILD.

Acteoside promotes B cell‐derived IL‐10 production and ameliorates autoimmunity
Meiling Wu, Sulan Yu, Yacun Chen, Wei Meng, Haiyong Chen, Jing He, Jiangang Shen, Xiang Lin

Pages: 875-885 | First Published: 31 May 2022

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Graphical Abstract

Acteoside promotes IL-10-producing capacity of B cells in a TLR4/PI3K dependent manner, and thus restores regulatory B cell function during autoimmune progression.

Pan‐cancer analysis of GALNTs expression identifies a prognostic of GALNTs feature in low grade glioma
Chengzhou Mao, Shi-Min Zhuang, Zijin Xia, Zhi-Wen Xiao, Chun-Xia Huang, Qiang Su, Jun Chen, Jing Liao

Pages: 887-899 | First Published: 24 January 2022

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Graphical Abstract

Development of a novel prognostic biomarker for LGG that may support evauation of immunotherapy strategies in brain cancer.

CAR NK‐92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo
Manting Liu, Wensou Huang, Yongjian Guo, Yubo Zhou, Cheng Zhi, Jingwu Chen, Junping Li, Jinping He, Hui Lian, Jingwen Zhou, Xiaodie Ye, Yuling Hu, Hong Hu, Zhaoyuan Liu, Jingjun Huang, Liteng Lin, Mingyue Cai, Xiaobin Wang, Jingzhen Huang, Zhenfeng Zhang, Kangshun Zhu, Qi Zhao, Bihui Cao

Pages: 901-911 | First Published: 28 January 2022

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Graphical Abstract

DLL3-CAR NK-92 cells showed significant anti-tumor effect on small cell lung cancer both in vitro and in vivo.

Tumor‐intrinsic CD21 expression impacts the response of B‐cell malignancy cells to CD19‐CAR‐T cells
Dan Li, Qiongyu Xu, Yutian Hu, Wenbing Wang, Shufeng Xie, Chunjun Zhao, Han Liu

Pages: 913-918 | First Published: 25 March 2022

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Graphical Abstract

Tumor-intrinsic CD21 impairs the target cell recognition and the cytotoxicity of the CD19-CAR-T cells.

Anticancer effects of disulfiram in T‐cell malignancies through NPL4‐mediated ubiquitin–proteasome pathway
Cunte Chen, Dingrui Nie, Youxue Huang, Xibao Yu, Zheng Chen, Mengjun Zhong, Xin Liu, Xianfeng Wang, Songnan Sui, Zhuandi Liu, Jiaxiong Tan, Zhi Yu, Yangqiu Li, Chengwu Zeng

Pages: 919-929 | First Published: 01 April 2022

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Graphical Abstract

Disulfiram eradicates T-cell malignancies by targeting the NPL4-mediated ubiquitin-proteasome pathway, and NPL4, ANAPC1, and PSMD2 might be potential biomarkers for risk stratification.

Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions
Weiwei Fu, Wenyan Wang, Jing zhang, Yang Zhao, Keyan Chen, Ye Wang, Jing Zhang, Ying Xiong, Xiaohuan Guo, Shigang Ding

Pages: 931-938 | First Published: 03 June 2022

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Graphical Abstract

A trajectory analysis of circulating ILCs and adaptive T cell lymphocytes subtypes in patients spanning a cascade of gastric lesions.

ERRATUM

Free Access
Erratum

Pages: 939-940 | First Published: 30 September 2022

This article is a correction.