JLB Vol 110 no 1 eTOC

Cover Image Journal of Leukocyte Biology
Volume 110, Issue 1
Focus Issue: Targeted Science — Special Focus Issue

Pages: 1-205

July 2021

Use the SLB member access portal to view this issue's contents.


Free Access
Issue Information

Pages: 1-5 | First Published: 29 June 2021


Free Access
As a matter of fat: Leptin, monocyte hyperactivation, and COVID‐19: A commentary to “Leptin correlates with monocytes activation and severe condition in COVID‐19 patients”
Antonio Recchiuti

Pages: 7-8 | First Published: 13 April 2021

Graphical Abstract

Discussion on leptin's effects on the pathophysiology of COVID-19 and its potential as a biomarker for this disease.


Free Access
Leptin correlates with monocytes activation and severe condition in COVID‐19 patients
Jingya Wang, Yinyin Xu, Xiaoli Zhang, Sheng Wang, Ziyi Peng, Jing Guo, Hongmei Jiang, Jing Liu, Ying Xie, Jingjing Wang, Xin Li, Juan Liao, Chao Wan, Lihua Yu, Jinsong Hu, Beizhong Liu, Zhiqiang Liu

Pages: 9-20 | First Published: 06 January 2021

Graphical Abstract

Leptin correlates severity of COVID-19, providing a possible mechanism whereby overweight cases are prone to develop severe conditions.

Free Access
Genome‐wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID‐19
Michael J. Corley PhD, Alina P.S. Pang PhD, Kush Dody, Philip A. Mudd MD, Bruce K. Patterson MD, Harish Seethamraju MD, Yaron Bram PhD, Michael J. Peluso MD, Leonel Torres, Nikita S. Iyer, Thomas A. Premeaux PhD, Stephen T. Yeung PhD, Vasuretha Chandar, Alain Borczuk MD, Robert E. Schwartz MD, PhD, Timothy J. Henrich MD, Steven G. Deeks MD, Jonah B. Sacha PhD, Lishomwa C. Ndhlovu MD, PhD

Pages: 21-26 | First Published: 19 January 2021

Graphical Abstract

A distinct epigenetic signature associated with severe COVID-19 exists in blood and is potentially useful for corroborating clinical assessments, informing pathogenic mechanisms, and revealing new therapeutic targets.


Free Access
Effects of mesenchymal stromal cell‐derived extracellular vesicles in acute respiratory distress syndrome (ARDS): Current understanding and future perspectives
Yue Su, Haiyan Guo, Qinghua Liu

Pages: 27-38 | First Published: 06 May 2021

Graphical Abstract

Describes the potential of Mesenchymal Stromal Cell-derived Extracellular Vesicles for the Treatment of Acute Respiratory Distress Syndrome


IL‐26 promotes the pathogenesis of malignant pleural effusion by enhancing CD4+IL‐22+ T‐cell differentiation and inhibiting CD8+ T‐cell cytotoxicity
Yiran Niu, Linlin Ye, Wenbei Peng, Zihao Wang, Xiaoshan Wei, Xu Wang, Yu Li, Siyu Zhang, Xuan Xiang, Qiong Zhou

Pages: 39-52 | First Published: 13 April 2021

Graphical Abstract

IL-26 appears to be a vital effector cytokine that contributes to the pathogenesis of malignant pleural effusion (MPE), and could be a prognostic indicator for MPE.

Serum sphingolipid profile in asthma
Chenglin Guo, Lina Sun, Linlin Zhang, Fawu Dong, Xu Zhang, Liu Yao, Chun Chang

Pages: 53-59 | First Published: 18 February 2021

Graphical Abstract

Liquid chromatography-mass spectrometry-based targeted metabolomic profiling was performed on serum samples from both patients with asthma and control subjects. Sphingomyelin (SM) levels were significantly decreased in the asthma patients compared to the healthy controls. SM levels were also decreased in the blood noneosinophilic asthma group compared with the blood eosinophilic asthma group and in the early-onset group compared with the late-onset group. SM may be involved in the pathogenesis of asthma and related to different inflammatory cell subtypes. SM is thought to be a protective factor in asthma.


Open Access
Hypoxia‐inducible factors not only regulate but also are myeloid‐cell treatment targets
Lovis Kling, Adrian Schreiber, Kai-Uwe Eckardt, Ralph Kettritz

Pages: 61-75 | First Published: 18 October 2020

Graphical Abstract

Reviews Hypoxia-inducible factors and how they control myeloid-cell functions; could be potential treatment targets for inflammatory diseases.

The functions of EZH2 in immune cells: Principles for novel immunotherapies
Fang-Fei Shao, Bo-Jin Chen, Guo-Qing Wu

Pages: 77-87 | First Published: 11 October 2020

Graphical Abstract

Review of EZH2 function in various immune cells to find ideas for cancer immunotherapies targeting EZH2 in immune cells.

Functional consequences of a close encounter between microglia and brain‐infiltrating monocytes during CNS pathology and repair
Alessandra Quarta, Zwi Berneman, Peter Ponsaerts

Pages: 89-106 | First Published: 06 November 2020

Graphical Abstract

Review discussing microglia and bran-infiltrating monocytes distinct roles following brain trauma or disease and how appropriate cellular models are necessary to investigate their neuroinflammatory responses in vitro.

Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis
Ting Shi, Laura Denney, Huazhang An, Ling-Pei Ho, Yuejuan Zheng

Pages: 107-114 | First Published: 06 November 2020

Graphical Abstract

Review describes the latest definitions and functions of lung macrophages during homeostasis and provides examples of their different roles in the development and progression of lung fibrosis.

From virus to inflammation, how influenza promotes lung damage
Mitchell Klomp, Sumit Ghosh, Sohail Mohammed, M. Nadeem Khan

Pages: 115-122 | First Published: 08 September 2020

Graphical Abstract

The pathogenic immune mechanisms contributing to influenza acute pathology are potential intervention targets to mitigate lung damage and improve viral immunity.


Surface translocator protein 18 kDa (TSPO) localization on immune cells upon stimulation with LPS and in ART‐treated HIV+ subjects
Lance K. Blevins, Robert B. Crawford, Diana J. Azzam, Tomás R. Guilarte, Norbert E. Kaminski

Pages: 123-140 | First Published: 17 November 2020

Graphical Abstract

Lipopolysaccharide and HIV infection in circulating leukocytes increased Translocator Protein 18 kDa (TSPO) on the cell surface of monocytes; suggests that cell surface TSPO in circulating leukocytes could serve as a peripheral blood-based biomarker of inflammation.

P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis
Samara Albayati, Harika Vemulapalli, Alexander Y. Tsygankov, Elisabetta Liverani

Pages: 141-153 | First Published: 26 November 2020

Graphical Abstract

Targeting platelets to control Treg proliferation and activity may be a promising strategy for treating sepsis.


Open Access
Effects of serum amyloid protein A on influenza A virus replication and viral interactions with neutrophils
Mitchell R. White, I-Ni Hsieh, Xavier De Luna, Kevan L. Hartshorn

Pages: 155-166 | First Published: 17 November 2020

Graphical Abstract

Serum amyloid a protein (SAA) bound to and inhibited influenza virus infectivity, but SAA free of bacterial products did not alter neutrophil responses.

Open Access
Mycobacterium leprae induces a tolerogenic profile in monocyte‐derived dendritic cells via TLR2 induction of IDO
Jéssica A. P. Oliveira, Mariana Gandini, Jorgenilce S. Sales, Sérgio K. Fujimori, Mayara G. M. Barbosa, Valber S. Frutuoso, Milton O. Moraes, Euzenir N. Sarno, Maria C. V. Pessolani, Roberta O. Pinheiro

Pages: 167-176 | First Published: 11 October 2020

Graphical Abstract

Mycobacterium leprae and its fractions are able to differentially modulate the activity and functionality of Indoleamine 2,3 dioxygenase in human monocyte-derived dendritic cells via a pathway that involves TLR2.

Open Access
Monocytic myeloid‐derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase‐2 inhibitors
Marthe Jøntvedt Jørgensen, Synne Jenum, Kristian Tonby, Rasmus Mortensen, Gerhard Walzl, Nelita Du Plessis, Anne Ma Dyrhol-Riise

Pages: 177-186 | First Published: 06 November 2020

Graphical Abstract

Study of Cyclooxygenase-2 inhibitors effects on monocytic Myeloid-derived suppressor cells in host directed therapy clinical trial supported by in-vitro data with reduction of suppressive soluble markers.

Tissue‐specific murine neutrophil activation states in health and inflammation
Jeffrey W. Chadwick, Noah Fine, William Khoury, Nikola Tasevski, Chun-Xiang Sun, Parastoo Boroumand, Amira Klip, Michael Glogauer

Pages: 187-195 | First Published: 04 November 2020

Graphical Abstract

Tissue neutrophils can be isolated and possess unique compartment-specific cluster of differentiation marker expression in health and disease


MDS‐associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells
Daniel A. Pollyea, Hyun Min Kim, Brett M. Stevens, Frank Fang-Yao Lee, Chelsea Harris, Brenna R. Hedin, Jennifer R. Knapp, Brian P. O'Connor, Craig T. Jordan, Eric M. Pietras, Aik Choon Tan, Scott Alper

Pages: 197-205 | First Published: 06 November 2020

Graphical Abstract

SF3B1 mutations enhance pro-inflammatory gene expression in blast cells, possibly contributing to an overall inflammatory milieu in MDS patients.