Gift bags from the sentinel cells of the immune system: The diverse role of dendritic cell‐derived extracellular vesicles
Amy L. Hodge, Amy A. Baxter, Ivan K. H. Poon
Version of Record online:26 October 2021
Graphical Abstract
Describes the functions of dendritic cell-derived extracellular vesicles in the context of antigen presentation, infection, cell death and immunotherapy.
Heparanase is a regulator of natural killer cell activation and cytotoxicity
Alyce J Mayfosh, Katharine J Goodall, Tien Nguyen, Nikola Baschuk, Mark D Hulett
Version of Record online:24 October 2021
Graphical Abstract
Heparanase contributes to natural killer cell cytotoxicity, activation, and cytokine production
NK cell‐based therapies for HIV infection: Investigating current advances and future possibilities
Arosh S. Perera Molligoda Arachchige
Version of Record online:20 October 2021
Graphical Abstract
Review of NK cell-based therapies for HIV infection
Adoptive transfer of GRP78‐treated dendritic cells alleviates insulitis in NOD mice
Xiaoqi Zhou, Muyang Yang, Yibing Lv, Heli Li, Sha Wu, Jie Min, Guanxin Shen, Yong He, Ping Lei
Version of Record online:13 October 2021
Graphical Abstract
Adoptively transferred GRP78-DCs, specifically homed to the inflamed pancreas, can promote beta cell survival, alleviate insulitis, and resolve inflammation in NOD mice.
Pro‐inflammatory polarization primes Macrophages to transition into a distinct M2‐like phenotype in response to IL‐4
Erin M. O'Brien, Kara L. Spiller
Version of Record online:13 October 2021
Graphical Abstract
M1 polarization primes macrophages to transition into a distinct M2 phenotype when compared with M2 macrophages derived from M0.
Differential training of innate leukocytes getting compartmentalized
Shuo Geng, Liwu Li
Version of Record online:12 October 2021
Graphical Abstract
Discussion on the discovery of compartmentalized innate immune training, and its relevance for the general context of innate immune memory dynamics.
Polymorphonuclear myeloid‐derived suppressor cells link inflammation and damage response after trauma
Xinyao Li, Jingping Liu, Zhe Xing, Jian Tang, Hengbiao Sun, Xiaogang Zhang, Shuaijun Lv, Ziyang Chen, Mengyu Shi, Meiqi Chen, Shaowen Zuo, Xiaoming Lyu, Yumei He
Version of Record online:12 October 2021
Graphical Abstract
Role of PMN-MDSCs in the anti-inflammatory immune response by regulation of the Treg/Th17 and Th2/Th1 balances after trauma.
CTCF: A novel fusion partner of ETO2 in a multiple relapsed acute myeloid leukemia patient
Jiao Li, Zhen Shen, Zheng Wang, Hongying Chao, Yi Xu, Zhao Zeng, Xiaosen Bian, Jun Zhang, Jinlan Pan, Weiwei Miao, Wenzhong Wu, Li Yao, Suning Chen, Lijun Wen
Version of Record online:08 October 2021
Graphical Abstract
CTCF is a translocation partner of ETO2 in acute myeloid leukemia; aids in understanding the pathogenic mechanisms in AML and may have future prognostic value.
Open Access
Transcription factor c‐Rel mediates communication between commensal bacteria and mucosal lymphocytes
Maik Luu, Kai Binder, Sabrina Hartmann, Meike Kespohl, Jasmin Bazant, Rossana Romero, Burkhard Schütz, Ulrich Steinhoff, Alexander Visekruna
Version of Record online:08 October 2021
Graphical Abstract
The transcription factor c-Rel regulates intestinal homeostasis and protects against pathogen colonization; c-Rel-deficient mice display defective IgA production in the intestine.
Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD‐L1
Ning Yang, Xuemei Liu, Xu Chen, Si Yu, Wenxiao Yang, Yao Liu
Version of Record online:08 October 2021
Graphical Abstract
Stem cells from human exfoliated deciduous teeth (SHED)-mediated rescue of Treg/Th17 balance via the sPD-L1/PD-1 pathway ameliorates the gland inflammation and dryness symptoms in SS mice, suggesting that SHED are a promising source for treating autoimmune diseases in a clinical setting.
Immunoregulation by type I interferons in the peritoneal cavity
Jasmine J. M. Chuah, Paul J. Hertzog, Nicole K. Campbell
Version of Record online:06 October 2021
Graphical Abstract
Review of how peritoneal immune cells and type I interferons protect against or promote disease in the peritoneal cavity.
Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Lin Li, Yuting Xia, Shijie Yuan, Fei Li, Xiaorong Xie, Yuan Luo, Xiang-Ping Yang, Ran He
Version of Record online:06 October 2021
Graphical Abstract
Blocking iron intake by anti-CD71 mAb impaired the response of TH17 cells, ameliorating autoimmune disease severity.
Open Access
Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia
Anaísa V. Ferreira, Rienke F. Uijen, Ozlem Bulut, Marien I. de Jonge, Jorge Domínguez-Andrés, Mihai G. Netea
Version of Record online:01 October 2021
Graphical Abstract
Splenectomy allows for a largely intact innate immune memory response, except for the reduction of trained immunity- induced neutrophilia.