Open Access
Animal models for studies of HIV‐1 brain reservoirs
Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D. Kevadiya, K. C. Kent Lloyd, Howard E. Gendelman, Santhi Gorantla, Larisa Y. Poluektova, Prasanta K. Dash
Version of Record online: 31 August 2022
Graphical Abstract
Review on recent rodent models that contain both human myeloid and T cells for future therapeutics and viral elimination investigations in CNS.
Single‐cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single‐center study
Yuan Shi, Weidong Ding, Weiying Gu, Yangling Shen, Haiqian Li, Zhuojun Zheng, Xiao Zheng, Yan Liu, Yun Ling
Version of Record online: 30 August 2022
Graphical Abstract
Single-cell resolution provide more precise biomarkers than usual which may substantially overcome intertumoral and intratumoral heterogeneity among Relapsed and Refractory DLBCL patients
Open Access
γδ T cell exhaustion: Opportunities for intervention
Di Chen, Yinglu Guo, Jiahuan Jiang, Pin Wu, Ting Zhang, Qichun Wei, Jian Huang, Dang Wu
Version of Record online: 24 August 2022
Graphical Abstract
Review of the characteristics, heterogeneity and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based anti-tumor immunotherapy.
In vitro‐induced Foxp3+CD8+ regulatory T cells suppress allergic IgE response in the gut
Shilpi Giri, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Saumitra Shaligram, Girdhari Lal
Version of Record online: 24 August 2022
Graphical Abstract
Foxp3+CD8+ Tregs suppress the allergic gut mucosal response and can be used as an adoptive cellular therapy to restore the oral tolerance to food antigens.
Epigallocatechin‐3‐gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis
Hongxuan Li, Cong Qiao, Lingyu Zhao, Qingxu Jing, Dongbo Xue, Yingmei Zhang
Version of Record online: 19 August 2022
Graphical Abstract
We identified the functions by which epigallocatechin-3-gallate effectively inhibits neutrophil elastase activity, reduces neutrophil extracellular trap formation, and attenuates systemic inflammatory response in acute pancreatitis.
Open Access
Put them to bed, and “do not disturb” brain microglia in SIV infection
Dennis Kolson
Version of Record online: 16 August 2022
Graphical Abstract
Discussion on the distinct brain myeloid cell response pathways in a study of SIV infection reveals a variable return of microglial homeostasis with virus suppression.
Immunotherapy targeting mesothelin in acute myeloid leukemia
Qingguang Wang, Rui Gong
Version of Record online: 10 August 2022
Graphical Abstract
The potential of immunotherapy against mesothelin in the treatment of acute myeloid leukemia.
Open Access
PMN‐MDSC in newborns: Regulation of the regulators
Jadwiga Jablonska, Sven Brandau
Version of Record online: 10 August 2022
Graphical Abstract
Discussion on molecular mechanisms that regulate beneficial functions of transiently induced PMN-MDSC in newborn mice
Open Access
Scylla, Charybdis, and navigating antimicrobial action in the neutrophil phagosome
William M. Nauseef
Version of Record online: 04 August 2022
Graphical Abstract
How the collaborative efforts of granule contents and locally generated oxidants are countered by microbial actions to survive.
Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology
Chi Ma, FuKun W. Hoffmann, Lance G. Nunes, Frank Urena, Anastasia Andrukhiv, Mariana Gerschenson, Matthew W. Pitts, Peter R. Hoffmann
Version of Record online: 02 August 2022
Graphical Abstract
Selenoprotein I increases during T cell activation and its expression is required for increased levels of the transcription factor, ROR gamma t, to drive Th17 differentiation.
Open Access
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection
Livio Azzoni, Leila B. Giron, Surya Vadrevu, Ling Zhao, Linden Lalley-Chareczko, Emily Hiserodt, Matthew Fair, Kenneth Lynn, Stacey Trooskin, Karam Mounzer, Mohamed Abdel-Mohsen, Luis J. Montaner
Version of Record online: 02 August 2022
Graphical Abstract
Long-term exposure to methadone may sustain immune activation and inflammation in ART-treated HIV-infected individuals, impairing their immune reconstitution outcomes.
Roles of the nucleus in leukocyte migration
Yutao Li, Mengqi Chen, Wakam Chang
Version of Record online: 02 August 2022
Graphical Abstract
Review of morphologies and mechanical properties of leukocyte nuclei, their regulation by nuclear envelope proteins, and their many roles in leukocyte migration.
Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Stacey A. Maskarinec, Margaret McKelvy, Kimberly Boyle, Halie Hotchkiss, Madelaine E. Duarte, Bechtler Addison, Nicholas Amato, Sanjay Khandelwal, Gowthami M. Arepally, Grace M. Lee
Version of Record online: 02 August 2022
Graphical Abstract
Differences in neutrophil functional capacity represent a fixed phenotype and are defined by distinct neutrophil gene expression profiles.
IL‐22 and Lactobacillus delbrueckii mitigate alcohol‐induced exacerbation of DSS‐induced colitis
Abigail R. Cannon, Esther H. Shim, Paulius V. Kuprys, Mashkoor A. Choudhry
Version of Record online: 02 August 2022
Graphical Abstract
Lactobacillus delbrueckii produced protective effects following alcohol consumption and DSS colitis, and that Lactobacillus delbrueckii utilized the IL-22/STAT3 signaling pathway in mediating these effects.