JLB Early View - September '22
Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue
Open Access

ARTICLE

Animal models for studies of HIV‐1 brain reservoirs
Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D. Kevadiya, K. C. Kent Lloyd, Howard E. Gendelman, Santhi Gorantla, Larisa Y. Poluektova, Prasanta K. Dash

Version of Record online: 31 August 2022

Description unavailable
Graphical Abstract

Review on recent rodent models that contain both human myeloid and T cells for future therapeutics and viral elimination investigations in CNS.

ARTICLES

Single‐cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single‐center study
Yuan Shi, Weidong Ding, Weiying Gu, Yangling Shen, Haiqian Li, Zhuojun Zheng, Xiao Zheng, Yan Liu, Yun Ling

Version of Record online: 30 August 2022

Description unavailable
Graphical Abstract

Single-cell resolution provide more precise biomarkers than usual which may substantially overcome intertumoral and intratumoral heterogeneity among Relapsed and Refractory DLBCL patients

Open Access

REVIEW

γδ T cell exhaustion: Opportunities for intervention
Di Chen, Yinglu Guo, Jiahuan Jiang, Pin Wu, Ting Zhang, Qichun Wei, Jian Huang, Dang Wu

Version of Record online: 24 August 2022

Description unavailable
Graphical Abstract

Review of the characteristics, heterogeneity and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based anti-tumor immunotherapy.

REGULAR ARTICLES

In vitro‐induced Foxp3+CD8+ regulatory T cells suppress allergic IgE response in the gut
Shilpi Giri, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Saumitra Shaligram, Girdhari Lal

Version of Record online: 24 August 2022

Description unavailable
Graphical Abstract

Foxp3+CD8+ Tregs suppress the allergic gut mucosal response and can be used as an adoptive cellular therapy to restore the oral tolerance to food antigens.

ARTICLES

Epigallocatechin‐3‐gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis
Hongxuan Li, Cong Qiao, Lingyu Zhao, Qingxu Jing, Dongbo Xue, Yingmei Zhang

Version of Record online: 19 August 2022

Description unavailable
Graphical Abstract

We identified the functions by which epigallocatechin-3-gallate effectively inhibits neutrophil elastase activity, reduces neutrophil extracellular trap formation, and attenuates systemic inflammatory response in acute pancreatitis.

Open Access

EDITORIAL COMMENTARY

Put them to bed, and “do not disturb” brain microglia in SIV infection
Dennis Kolson

Version of Record online: 16 August 2022

Description unavailable
Graphical Abstract

Discussion on the distinct brain myeloid cell response pathways in a study of SIV infection reveals a variable return of microglial homeostasis with virus suppression.

REVIEW

Immunotherapy targeting mesothelin in acute myeloid leukemia
Qingguang Wang, Rui Gong

Version of Record online: 10 August 2022

Description unavailable
Graphical Abstract

The potential of immunotherapy against mesothelin in the treatment of acute myeloid leukemia.

Open Access

EDITORIAL COMMENTARY

PMN‐MDSC in newborns: Regulation of the regulators
Jadwiga Jablonska, Sven Brandau

Version of Record online: 10 August 2022

Description unavailable
Graphical Abstract

Discussion on molecular mechanisms that regulate beneficial functions of transiently induced PMN-MDSC in newborn mice

Open Access

EDITORIALS

Scylla, Charybdis, and navigating antimicrobial action in the neutrophil phagosome
William M. Nauseef

Version of Record online: 04 August 2022

Description unavailable
Graphical Abstract

How the collaborative efforts of granule contents and locally generated oxidants are countered by microbial actions to survive.

ARTICLES

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology
Chi Ma, FuKun W. Hoffmann, Lance G. Nunes, Frank Urena, Anastasia Andrukhiv, Mariana Gerschenson, Matthew W. Pitts, Peter R. Hoffmann

Version of Record online: 02 August 2022

Description unavailable
Graphical Abstract

Selenoprotein I increases during T cell activation and its expression is required for increased levels of the transcription factor, ROR gamma t, to drive Th17 differentiation.

Open Access

ARTICLES

Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection
Livio Azzoni, Leila B. Giron, Surya Vadrevu, Ling Zhao, Linden Lalley-Chareczko, Emily Hiserodt, Matthew Fair, Kenneth Lynn, Stacey Trooskin, Karam Mounzer, Mohamed Abdel-Mohsen, Luis J. Montaner

Version of Record online: 02 August 2022

Description unavailable
Graphical Abstract

Long-term exposure to methadone may sustain immune activation and inflammation in ART-treated HIV-infected individuals, impairing their immune reconstitution outcomes.

ARTICLES

Roles of the nucleus in leukocyte migration
Yutao Li, Mengqi Chen, Wakam Chang

Version of Record online: 02 August 2022

Description unavailable
Graphical Abstract

Review of morphologies and mechanical properties of leukocyte nuclei, their regulation by nuclear envelope proteins, and their many roles in leukocyte migration.

ARTICLE

Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Stacey A. Maskarinec, Margaret McKelvy, Kimberly Boyle, Halie Hotchkiss, Madelaine E. Duarte, Bechtler Addison, Nicholas Amato, Sanjay Khandelwal, Gowthami M. Arepally, Grace M. Lee

Version of Record online: 02 August 2022

Description unavailable
Graphical Abstract

Differences in neutrophil functional capacity represent a fixed phenotype and are defined by distinct neutrophil gene expression profiles.

ARTICLE

IL‐22 and Lactobacillus delbrueckii mitigate alcohol‐induced exacerbation of DSS‐induced colitis
Abigail R. Cannon, Esther H. Shim, Paulius V. Kuprys, Mashkoor A. Choudhry

Version of Record online: 02 August 2022

Description unavailable
Graphical Abstract

Lactobacillus delbrueckii produced protective effects following alcohol consumption and DSS colitis, and that Lactobacillus delbrueckii utilized the IL-22/STAT3 signaling pathway in mediating these effects.