JLB Vol 112 Issue 6 TOC

Cover Image Journal of Leukocyte Biology
Volume 112, Issue 6

Pages: 1357-1716

December 2022

 

Browse table of contents

ISSUE INFORMATION

Free Access
Issue Information

Pages: 1357-1363 | First Published: 25 November 2022

LETTERS TO EDITOR

Free Access
Circulating IL‐6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID‐19
Vanessa Granger, Audrey Fels, Thomas Huet, Jean-Louis Laplanche, Sophie Laplanche, Gilles Chatellier, Hélène Beaussier, Sylvie Chollet-Martin, Luc de Chaisemartin, Gilles Hayem

Pages: 1365-1367 | First Published: 15 June 2022

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Graphical Abstract

Added data on circulating IL-6 levels can predict COVID-19 severity and IL1RA efficiency.

EDITORIAL COMMENTARY

Aging and macrophages: Not standing the test of time?
Suhas Sureshchandra, Ilhem Messaoudi

Pages: 1369-1370 | First Published: 29 June 2022

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Graphical Abstract

Advanced age leads to significant disruption in function of alveolar macrophages, which play a critical role in tissue homeostasis and anti-microbial defense.

SPOTLIGHT ON LEADING EDGE RESEARCH

Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury
Devin M. Boe, Holly J. Hulsebus, Kevin M. Najarro, Juliet E. Mullen, Hyunmin Kim, Aik Choon Tan, Rachel H. McMahan, Elizabeth J. Kovacs

Pages: 1371-1386 | First Published: 19 September 2022

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Graphical Abstract

Healthy aging alters alveolar macrophage phenotype and responses to acute physiologic distress involving age-associated dysregulation of glucocorticoid signaling.

Cell Development, Differentiation and Trafficking

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology
Chi Ma, FuKun W. Hoffmann, Lance G. Nunes, Frank Urena, Anastasia Andrukhiv, Mariana Gerschenson, Matthew W. Pitts, Peter R. Hoffmann

Pages: 1387-1397 | First Published: 02 August 2022

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Graphical Abstract

Selenoprotein I increases during T cell activation and its expression is required for increased levels of the transcription factor, ROR gamma t, to drive Th17 differentiation.

Inflammation, Extracellular Mediators, and Effector Molecules

The extracellular sialidase NEU3 primes neutrophils
Sara A. Kirolos, Darrell Pilling, Richard H. Gomer

Pages: 1399-1411 | First Published: 28 July 2022

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The extracellular sialidase enzyme NEU3 is upregulated in fibrotic lesions, and here we show that extracellular recombinant human NEU3 partially desialylates and primes human neutrophils.

Dectin‐1 signaling in neutrophils up‐regulates PD‐L1 and triggers ROS‐mediated suppression of CD4+ T cells
M. Elizabeth Deerhake, Emre D. Cardakli, Mari L. Shinohara

Pages: 1413-1425 | First Published: 08 September 2022

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Mechanisms by which Dectin-1 signaling in neutrophils promotes a cellular phenotype with T cell-suppressive properties.

Epigallocatechin‐3‐gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis
Hongxuan Li, Cong Qiao, Lingyu Zhao, Qingxu Jing, Dongbo Xue, Yingmei Zhang

Pages: 1427-1443 | First Published: 19 August 2022

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We identified the functions by which epigallocatechin-3-gallate effectively inhibits neutrophil elastase activity, reduces neutrophil extracellular trap formation, and attenuates systemic inflammatory response in acute pancreatitis.

ILC3‐like ILC2 subset increases in minimal persistent inflammation after acute type II inflammation of allergic rhinitis and inhibited by Biminkang: Plasticity of ILC2 in minimal persistent inflammation
Xiang-Jing Chen, Cheng Liu, Shan Zhang, Li-Feng Zhang, Wei Meng, Xin Zhang, Meng Sun, Yue Zhang, Ren-Zhong Wang, Cheng-Fang Yao

Pages: 1445-1455 | First Published: 26 September 2022

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ILC3-like ILC characterized with IL-5+IL-17A+IL-23R+ was significantly increased of the airway in minimal persistent inflammation and it could be inhibited by the Chinese herbal medicine Biminkang.

Host Defense and Pathophysiology

Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype
Carolina G. Dolislager, Sean M. Callahan, Dallas R. Donohoe, Jeremiah G. Johnson

Pages: 1457-1470 | First Published: 22 July 2022

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Campylobacter jejuni infection of neutrophils results in differentiation of a subtype which activates HIF-1 and NF-κB in colonocytes and decreases TCRζ in T cells.

IL‐22 and Lactobacillus delbrueckii mitigate alcohol‐induced exacerbation of DSS‐induced colitis
Abigail R. Cannon, Esther H. Shim, Paulius V. Kuprys, Mashkoor A. Choudhry

Pages: 1471-1484 | First Published: 02 August 2022

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Lactobacillus delbrueckii produced protective effects following alcohol consumption and DSS colitis, and that Lactobacillus delbrueckii utilized the IL-22/STAT3 signaling pathway in mediating these effects.

Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Stacey A. Maskarinec, Margaret McKelvy, Kimberly Boyle, Halie Hotchkiss, Madelaine E. Duarte, Bechtler Addison, Nicholas Amato, Sanjay Khandelwal, Gowthami M. Arepally, Grace M. Lee

Pages: 1485-1495 | First Published: 02 August 2022

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Graphical Abstract

Differences in neutrophil functional capacity represent a fixed phenotype and are defined by distinct neutrophil gene expression profiles.

TRANSLATIONAL AND CLINICAL IMMUNOLOGY

In vitro‐induced Foxp3+CD8+ regulatory T cells suppress allergic IgE response in the gut
Shilpi Giri, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Saumitra Shaligram, Girdhari Lal

Pages: 1497-1507 | First Published: 24 August 2022

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Foxp3+CD8+ Tregs suppress the allergic gut mucosal response and can be used as an adoptive cellular therapy to restore the oral tolerance to food antigens.

Meeting: Targeted Science Issue - 2021 SLB Virtual Annual Meeting

Guest Editors: Vidula Vachharajani, Laura Nagy

REVIEWS

Open Access
Sepsis, pyruvate, and mitochondria energy supply chain shortage
Charles E. McCall, Xuewei Zhu, Manal Zabalawi, David Long, Matthew A. Quinn, Barbara K. Yoza, Peter W. Stacpoole, Vidula Vachharajani

Pages: 1509-1514 | First Published: 22 July 2022

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This review summarizes our research identifying mitochondrial pyruvate oxidative metabolism and its coupling to tricarboxylic (TCA) cycle resistance and disease tolerance energetics as pathway to sepsis survival.

Open Access
Metabolic impact of adipose tissue macrophages in the early postnatal life
Tamás Röszer

Pages: 1515-1524 | First Published: 28 July 2022

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Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long-term impact on obesity status.

Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis
Jaimar C. Rincon, Philip A. Efron, Lyle L. Moldawer

Pages: 1525-1534 | First Published: 04 October 2022

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Critically ill sepsis survivor patients show specific immunological endotypes, secondary to a persistent maladaptive reprioritization of myelopoiesis and pathological activation of myeloid cells.

A novel strategy to dissect multifaceted macrophage function in human diseases
Keaton Karlinsey, Lili Qu, Alyssa J. Matz, Beiyan Zhou

Pages: 1535-1542 | First Published: 21 June 2022

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Review of the current models to understand dynamic actions of macrophages in various diseases and new strategies to characterize their molecular network using single-cell transcriptomics.

PRIMARY RESEARCH

Contact‐dependent, polarized acidification response during neutrophil–epithelial interactions
Ian M. Cartwright, Alexander S. Dowdell, Camila Hanson, Rachael E. Kostelecky, Nichole Welch, Calen A. Steiner, Sean P. Colgan

Pages: 1543-1553 | First Published: 08 June 2022

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Inflammatory acidosis represents a polarized neutrophil-epithelial dependent response independent of myeloperoxidase and ion efflux.

Divergent Golgi trafficking limits B cell‐mediated IgG sialylation
Leandre M. Glendenning, Julie Y. Zhou, Kalob M. Reynero, Brian A. Cobb

Pages: 1555-1566 | First Published: 21 June 2022

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B cells secrete IgG antibodies through a pathways that promotes exposure to the enzyme Fut8 to promote N-glycan core fucosylation, yet limits exposure to ST6Gal1 to minimize alpha2,6 sialylation.

Meeting: Targeted Science Issue - 6th International Conference on Cancer Precision Medicine 2021

Guest Editors: Xiubao Ren, Jingting Jiang, Xiao Zheng, Quanli Gao, Jiuwei Cui, Yunbin Ye, and Feng Wei

PRIMARY RESEARCH

Dysregulated Th1 cells in lung squamous cell carcinoma
Jiahui Wang, Jian Zhou, Qiuru Zhou, Ying Qi, Peng Zhang, Cihui Yan, Xiubao Ren

Pages: 1567-1576 | First Published: 10 June 2022

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Th1 cells' function is suppressed in LUSC. Through scRNA-seq, the decreased Th1 cells' function is associated with ER stress, which requires further study.

Altered MUC1 epitope‐specific CTLs: A potential target for immunotherapy of pancreatic cancer
Jingwen Hong, Guoxiang Guo, Suxin Wu, Shengzhe Lin, Zhifeng Zhou, Shuping Chen, Chunmei Ye, Jieyu Li, Wansong Lin, Yunbin Ye

Pages: 1577-1590 | First Published: 12 October 2022

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Morphine with or without ART dysregulates functions of primary human macrophages, which may contribute to neuropathogenesis in opioid users living with HIV.

Relationship and prognostic significance of IL‐33, PD‐1/PD‐L1, and tertiary lymphoid structures in cervical cancer
Ying Zhang, Jing Li, Fan Yang, Xiying Zhang, Xiubao Ren, Feng Wei

Pages: 1591-1603 | First Published: 02 May 2022

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IL-33, TLS and PD-L1 are potentially valuable prognostic predictor for cervical cancer.

The prognostic value of a 4‐factor neoimmunologic score system in non‐small cell lung cancer
Fan Yang, Ziqing Zeng, Yuan Li, Dong Zhang, Feng Wei, Hua Zhao, Peng Zhang, Xiubao Ren

Pages: 1605-1619 | First Published: 08 September 2022

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A neoimmunologic score system was constructed based on 4 variables including CD3+, CD8+, FoxP3+, and PD-1+ immune cell densities in non-small cell lung cancer.

Dynamic immune ecosystem of dengue infection revealed by single‐cell sequencing
Gang Xu, Yueying Gao, Tao Pan, Si Li, Ya Zhang, Jing Guo, Zhanyu Tian, Juan Xu, Yongsheng Li, Xia Li

Pages: 1621-1631 | First Published: 29 June 2022

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Immune ecosystem of dengue infection analyzed to provide insights into the pathogenesis and treatment.

Single‐cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single‐center study
Yuan Shi, Weidong Ding, Weiying Gu, Yangling Shen, Haiqian Li, Zhuojun Zheng, Xiao Zheng, Yan Liu, Yun Ling

Pages: 1633-1648 | First Published: 30 August 2022

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Single-cell resolution provide more precise biomarkers than usual which may substantially overcome intertumoral and intratumoral heterogeneity among Relapsed and Refractory DLBCL patients

Meeting: Targeted Science Issue - The 9th International Gamma Delta T Cell Conference for 2021

Guest Editors: Zhinan Yin, Wenwei Tu, Jian Huang, Jianlei Hao, and Zheng Xiang

REVIEWS

The role of γδ T17 cells in cardiovascular disease
Shaoxue Ling, Zonghao You, Yang Li, Jian Zhang, Shuwu Zhao, Yongzhi He, Xi Chen

Pages: 1649-1661 | First Published: 08 September 2022

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This review provides a more comprehensive understanding of the biology of γδ cells and their role in CVD.

γδ T cells: The potential role in liver disease and implications for cancer immunotherapy
He Ren, WanJing Li, Xin Liu, Na Zhao

Pages: 1663-1668 | First Published: 13 September 2022

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Graphical Abstract: Review on the molecular mechanisms of γδ T cells in liver disease and its implications for clinical immunotherapy.

Open Access
γδ T cell exhaustion: Opportunities for intervention
Di Chen, Yinglu Guo, Jiahuan Jiang, Pin Wu, Ting Zhang, Qichun Wei, Jian Huang, Dang Wu

Pages: 1669-1676 | First Published: 24 August 2022

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Review of the characteristics, heterogeneity and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based anti-tumor immunotherapy.

PRIMARY RESEARCH

IL‐1β/NF‐κB signaling inhibits IGF‐1 production via let‐7f‐5p in dendritic epidermal T cells
Yashu Li, Juan Wang, Yangping Wang, Weifeng He, Yixin Zhang, Yan Liu

Pages: 1677-1690 | First Published: 19 September 2022

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Molecular mechanisms identified by which IL-1β/NF-κB down-regulates IGF-1 expression by let-7f-5p in dendritic epidermal T cells.

TIGIT‐expressing zoledronate‐specific γδ T cells display enhanced antitumor activity
Hongqin You, Huifang Zhu, Yajie Zhao, Jindong Guo, Quanli Gao

Pages: 1691-1700 | First Published: 10 November 2022

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TIGIT expressing, ZOL-specific γδ T cells are not exhausted, but more functional in antitumor immune response.

Reviving human γδT cells from apoptosis induced by IL‐12/18 via p‐JNK inhibition
Yuan Song, Huey Yee Teo, Yonghao Liu, Xiaomeng Zhang, Jinmiao Chen, Yongliang Zhang, Haiyan Liu

Pages: 1701-1716 | First Published: 30 June 2022

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p-JNK inhibitor treatment effectively revived human γδT cells from the apoptosis induced by IL-12/18 and maintained their enhanced IFN-γ production and cytotoxicity against tumor cells.