JLB Vol 111 Issue 3 TOC

Cover Image Journal of Leukocyte Biology
Volume 111, Issue 3

Pages: 509-734

March 2022

 

ISSUE INFORMATION

Free Access
Issue Information

Pages: 509-514 | First Published:25 February 2022

EDITORIAL

Maternal–fetal tolerance: Not just a uterine affair
Timothy J. Boly, Jennifer R. Bermick

Pages: 515-517 | First Published:10 January 2022

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Discussion on systemic maternal immune cells aiding in maternal-fetal tolerance during pregnancy.

SPOTLIGHT ON LEADING EDGE RESEARCH

Specific innate immune cells uptake fetal antigen and display homeostatic phenotypes in the maternal circulation
Marcia Arenas-Hernandez, Roberto Romero, Meyer Gershater, Li Tao, Yi Xu, Valeria Garcia-Flores, Errile Pusod, Derek Miller, Jose Galaz, Kenichiro Motomura, George Schwenkel, Robert Para, Nardhy Gomez-Lopez

Pages: 519-538 | First Published:10 December 2021

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Novel interactions demonstrated between specific maternal circulating innate immune cells and fetal antigens that may contribute to the systemic mechanisms of maternal-fetal crosstalk.

CELL DEVELOPMENT, DIFFERENTIATION, AND TRAFFICKING

Acetyl‐CoA carboxylase‐1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO
Thuy Nguyen-Phuong, Hyunwoo Chung, Jiyun Jang, Jung-Sik Kim, Chung-Gyu Park

Pages: 539-551 | First Published:24 May 2021

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Graphical Abstract

Blocking acetyl-CoA carboxylases 1 and 2-(ACC1/2) deprives of fatty acids, through a fatty acid oxidation pathway, in activated dendritic cells (DC), inducing a semi-mature DC phenotype with a maturation-resistant feature.

LncRNA TUG1 ameliorates diabetic nephropathy via inhibition of PU.1/RTN1 signaling pathway
Dongdong Meng, Lina Wu, Zhifu Li, Xiaojun Ma, Shuiying Zhao, Di Zhao, Guijun Qin

Pages: 553-562 | First Published:01 June 2021

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Graphical Abstract

Taurine up-regulated gene 1 (TUG1) reduces endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells and ameliorates diabetic nephropathy by inhibiting transcription factor PU.1.

RECEPTORS, SIGNAL TRANSDUCTION AND GENES

The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase‐induced mesangial cell proliferation
Yuxuan Zhen, Tracy L. McGaha, Fred D. Finkelman, Wen-Hai Shao

Pages: 563-571 | First Published:04 July 2021

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Axl mediates mesangial cell phagocytosis of apoptotic cells and promotes mesangial cell proliferation by activating NF-kB and mTORC1.

INFLAMMATION, EXTRACELLULAR MEDIATORS, AND EFFECTOR MOLECULES

Human monocytes store and secrete preformed CCL5, independent of de novo protein synthesis
Arvin Tejnarine Persaud, Stephen Andrew Bennett, Laxshaginee Thaya, Jonathan Burnie, Christina Guzzo

Pages: 573-583 | First Published:11 June 2021

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Resting human monocytes have intracellular storage pools of CCL5 that are associated with compartments containing Rab11A and CD63, enabling rapid release without the need for de novo protein synthesis.

Melanoma‐derived extracellular vesicles skew neutrophils into a pro‐tumor phenotype
Daniel Guimarães-Bastos, Ana Clara Frony, Christina Barja-Fidalgo, João Alfredo Moraes

Pages: 585-596 | First Published:27 May 2021

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Graphical Abstract

Extracellular vesicles produced by a melanoma cell line, MV3, induce phenotypic and functional changes in human neutrophils.

Open Access
Activation of human γδ T cells and NK cells by Staphylococcal enterotoxins requires both monocytes and conventional T cells
Manuel Mata Forsberg, Claudia Arasa, Willemien van Zwol, Sibel Uzunçayir, Anna Schönbichler, Paulina Regenthal, Jenny Schelin, Karin Lindkvist-Petersson, Sophia Björkander, Eva Sverremark-Ekström

Pages: 597-609 | First Published:11 June 2021

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Unconventional T cells and NK cells require IL-12, monocytes, conventional T cells, and a mature immune system to efficiently respond to Staphylococcal enterotoxins in vitro.

FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate‐conditioned and diabetic macrophages
Priya Gupta, Gaurav Sharma, Amit Lahiri, Manoj Kumar Barthwal

Pages: 611-627 | First Published:20 July 2021

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In palmitate-conditioned wild type and diabetic mice macrophages, FOXO3a acetylation inhibits PINK1 expression and mitophagy leading to enhanced mtROS, mtDNA release, and inflammasome activation.

Open Access
Macrophage inflammatory state influences susceptibility to lysosomal damage
Amanda O. Wong, Matangi Marthi, Amanda Haag, Irene A. Owusu, Christiane E. Wobus, Joel A. Swanson

Pages: 629-639 | First Published:14 July 2021

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TLR and cytokine stimulation increase macrophage resistance to lysosomal damage through multiple distinct signaling pathways.

LncRNA NEAT1_1 suppresses tumor‐like biologic behaviors of fibroblast‐like synoviocytes by targeting the miR‐221‐3p/uPAR axis in rheumatoid arthritis
Manli Wang, Yixiong Chen, Xuan Bi, Xiqing Luo, Zuoyu Hu, Yan Liu, Xiaoyi Shi, Weizhen Weng, Biyao Mo, Yan Lu, Yunfeng Pan

Pages: 641-653 | First Published:12 July 2021

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Graphical Abstract

Urokinase-type plasminogen activator receptor and the function of nuclear paraspeckle assembly transcript 1 _1 in regulating rheumatoid arthritis fibroblast-like synoviocytes.

HOST DEFENSE AND PATHOPHYSIOLOGY

Open Access
Elevated F‐EDN correlates with mucosal eosinophil degranulation in patients with IBS—A possible association with microbiota?
Maite Casado-Bedmar, Felipe Meira de-Faria, Olga Biskou, Carl Mårten Lindqvist, Purnika Damindi Ranasinghe, Olga Bednarska, Christer Peterson, Susanna A. Walter, Marie Carlson, Åsa V. Keita

Pages: 655-665 | First Published:21 June 2021

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Fecal eosinophil-derived neurotoxin (F-EDN) levels are correlated to degranulation of eosinophils in the colon of irritable bowel syndrome (IBS) patients.

SYSTEM BIOLOGY AND IMMUNOGENETICS

Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes
Catherine B. Anders PhD, Tyler M.W. Lawton, Hannah L. Smith, Jamie Garret, Margaret M. Doucette DO, Mary Cloud B. Ammons PhD

Pages: 667-693 | First Published:09 August 2021

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Macrophage functional plasticity of six macrophage phenotypes correlates with unique distinctions in cell-surface marker expression, signal protein secretion, transcriptomics profiles, and metabolic processes.

REVIEWS

Role of IL‐6 in dendritic cell functions
Yu-Dong Xu, Mi Cheng, Pan-Pan Shang, Yong-Qing Yang

Pages: 695-709 | First Published:18 August 2021

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Reviews the role of IL-6, when generated in an inflammatory context or as derived from dendritic cells (DCs), in modulating the biological function and activation status of DCs.

The interaction between iNKT cells and B cells
Tong Zhu, Rongli Wang, Heather Miller, Lisa S. Westerberg, Lu Yang, Fei Guan, Pamela Lee, Quan Gong, Yan Chen, Chaohong Liu

Pages: 711-723 | First Published:27 July 2021

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Reviews the interaction between invariant natural killer T cells (iNKTs) and B cells and their impact on the treatment of infections, autoimmune diseases, cancers, and other diseases.

Review - COVID-19 and Related Topics

Free Access
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine‐induced thrombotic thrombocytopenia (VITT)
Junaid Kashir, Ayesha Rahman Ambia, Areez Shafqat, Muhammad Raihan Sajid, Khaled AlKattan, Ahmed Yaqinuddin

Pages: 725-734 | First Published:01 September 2021

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Review on the scientific premise for incidence of vaccine-induced thrombotic thrombocytopenia as a result of inflammatory reactions mediated via IL-1β/NLRP3 inflammasome activation and consequent overproduction of NETs.