Reviving human γδT cells from apoptosis induced by IL‐12/18 via p‐JNK inhibition
Yuan Song, Huey Yee Teo, Yonghao Liu, Xiaomeng Zhang, Jinmiao Chen, Yongliang Zhang, Haiyan Liu
Version of Record online:30 June 2022
Graphical Abstract
p-JNK inhibitor treatment effectively revived human γδT cells from the apoptosis induced by IL-12/18 and maintained their enhanced IFN-γ production and cytotoxicity against tumor cells.
Ginsenoside Rg1 ameliorates sepsis‐induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells
Jun Guo, Rong Wang, Fei Min
Version of Record online:30 June 2022
Graphical Abstract
Ginsenoside Rg1 exerted an alleviating effect on SI-AKI, likely resulting from the inhibition of ferroptosis in renal TECs through FSP1.
Aging and macrophages: Not standing the test of time?
Suhas Sureshchandra, Ilhem Messaoudi
Version of Record online:29 June 2022
Graphical Abstract
Advanced age leads to significant disruption in function of alveolar macrophages, which play a critical role in tissue homeostasis and anti-microbial defense.
Dynamic immune ecosystem of dengue infection revealed by single‐cell sequencing
Gang Xu, Yueying Gao, Tao Pan, Si Li, Ya Zhang, Jing Guo, Zhanyu Tian, Juan Xu, Yongsheng Li, Xia Li
Version of Record online:29 June 2022
Graphical Abstract
Immune ecosystem of dengue infection analyzed to provide insights into the pathogenesis and treatment.
Early differentiated CD28+ CD27+ T lymphocytes as a biomarker for short and long‐term outcomes in older patients with pneumonia
Teresa Franco-Leyva, Olga H. Torres, María Encarnación Saez Prieto, Gemma Boera-Carnicero, Álvaro Santos, Sandra Clotet, Daniel Albert-Jares, Yasmin El-Ebiary, Manuela Agustí-Martí, Jordi Casademont, Cándido Juárez, Laura Martínez-Martínez
Version of Record online:23 June 2022
Graphical Abstract
Increased levels of early differentiated CD28+ CD27+ T lymphocytes at admission for pneumonia in older people is a predictor of better survival and no hospital readmission.
Joost J. Oppenheim: 1934–2022
Sharon M. Wahl, Howard A. Young
Version of Record online:23 June 2022
Graphical Abstract
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IL‐17A produced by invariant natural killer T cells and CD3+CD56+αGalcer‐CD1d tetramer– T cells promote liver fibrosis in patients with primary biliary cholangitis
Hongyu Jia, Jianing Chen, Xujun Zhang, Kefan Bi, Hetong Zhou, Tianxing Liu, Jia Xu, Hongyan Diao
Version of Record online:22 June 2022
Graphical Abstract
Since IL-17A was produced by invariant natural killer T cells and CD3+CD56+αGalcer-CD1d tetramer- T cells promote PBC-related fibrosis, they could be potentially used as a novel target for immunotherapy in the patients with primary biliary cholangitis.
A novel strategy to dissect multifaceted macrophage function in human diseases
Keaton Karlinsey, Lili Qu, Alyssa J. Matz, Beiyan Zhou
Version of Record online:21 June 2022
Graphical Abstract
Review of the current models to understand dynamic actions of macrophages in various diseases and new strategies to characterize their molecular network using single-cell transcriptomics.
Divergent Golgi trafficking limits B cell‐mediated IgG sialylation
Leandre M. Glendenning, Julie Y. Zhou, Kalob M. Reynero, Brian A. Cobb
Version of Record online:21 June 2022
Graphical Abstract
B cells secrete IgG antibodies through a pathways that promotes exposure to the enzyme Fut8 to promote N-glycan core fucosylation, yet limits exposure to ST6Gal1 to minimize alpha2,6 sialylation.
Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs‐MDSCs in newborns
Michela Perego, Shuyu Fu, Yingjiao Cao, Andrew Kossenkov, Meng Yao, Kevin Alicea-Torres, Wangkai Liu, Zhilong Jiang, Zhihong Chen, Serge Y. Fuchs, Jie Zhou, Dmitry I. Gabrilovich
Version of Record online:21 June 2022
Graphical Abstract
A mechanism of temporal control of PMN-MDSC in newborns identified that involves lactoferrin mediated positive and type I interferon mediated negative regulation.
Open Access
Klf10 favors Mycobacterium tuberculosis survival by impairing IFN‐γ production and preventing macrophages reprograming to macropinocytosis
Edgardo Madrid-Paulino, Dulce Mata-Espinosa, Juan Carlos León-Contreras, Isela Serrano-Fujarte, Sol Díaz de León-Guerrero, Tomás Villaseñor, Lucero Ramon-Luing, José L. Puente, Leslie Chavez-Galan, Rogelio Hernández-Pando, Leonor Pérez-Martínez, Gustavo Pedraza-Alva
Version of Record online:21 June 2022
Graphical Abstract
By inducing Klf10 expression, Mycobacterium tuberculosis decreases INF-γ production and impairs an INF-γ-mediated autocrine loop that promotes macrophages macropinocytosis, thus favoring survival and infection.
Open Access
Current strategies to induce selective killing of HIV‐1‐infected cells
Grant R. Campbell, Stephen A. Spector
Version of Record online:16 June 2022
Graphical Abstract
Overview of current strategies to kill HIV-1-infected cells.
In silico design of a TLR4‐mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformatics
Kiarash Saleki, Mohamad Hosein Mohamadi, Mohamad Banazadeh, Parsa Alijanizadeh, Nima Javanmehr, Ramtin Pourahmad, Hamid Reza Nouri
Version of Record online:16 June 2022
Graphical Abstract
Use of reverse vaccinology techniques to target multiple commonly misfolded proteins in ALS, such as SOD-1 and TDP-43.
Free Access
Circulating IL‐6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID‐19
Vanessa Granger, Audrey Fels, Thomas Huet, Jean-Louis Laplanche, Sophie Laplanche, Gilles Chatellier, Hélène Beaussier, Sylvie Chollet-Martin, Luc de Chaisemartin, Gilles Hayem
Version of Record online:15 June 2022
Graphical Abstract
Added data on circulating IL-6 levels can predict COVID-19 severity and IL1RA efficiency.
Human mucosal Vα7.2+CD161hi T cell distribution at physiologic state and in Helicobacter pylori infection
Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael N.T. Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J. Corbett, Rangsima Reantragoon
Version of Record online:15 June 2022
Graphical Abstract
Study of human Vα7.2+CD161hi T cell distribution in peripheral blood and different sites of gastrointestinal tract, its TCR characteristics and response to Helicobacter pylori infection
R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking
Kathy Yuen Yee Chan, Po Yee Chung, Chi Zhang, Ellen Ngar Yun Poon, Alex Wing Kwan Leung, Kam Tong Leung
Version of Record online:13 June 2022
Graphical Abstract
R4 RGS proteins exhibit profound impact on the trafficking of blood stem cells and represent promising drug targets for enhancing clinical stem cell transplantation.
c‐Rel‐dependent monocytes are potent immune suppressor cells in cancer
Ting Li, Mayassa J. Bou-Dargham, Norman Fultang, Xinyuan Li, Warren S. Pear, Honghong Sun, Youhai H. Chen
Version of Record online:13 June 2022
Graphical Abstract
Data to support: (i) c-Rel-dependent monocytes (rMos) are a new subset of myeloid suppressor cells with a unique set of markers; and (ii) the differentiation of rMos is specified by a lineage-specific transcriptional complex called c-Rel enhanceosome.
Open Access
Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques
Andrew J. Trease, Meng Niu, Brenda Morsey, Chittibabu Guda, Siddappa N. Byrareddy, Shilpa Buch, Howard S. Fox
Version of Record online:10 June 2022
Graphical Abstract
ScRNA-seq of rhesus monkey microglia reveals clusters of cells in activated states in the setting of SIV infection, which is primarily reversed by suppressing viremia with combination antiretroviral therapy.
Dysregulated Th1 cells in lung squamous cell carcinoma
Jiahui Wang, Jian Zhou, Qiuru Zhou, Ying Qi, Peng Zhang, Cihui Yan, Xiubao Ren
Version of Record online:10 June 2022
Graphical Abstract
Th1 cells' function is suppressed in LUSC. Through scRNA-seq, the decreased Th1 cells' function is associated with ER stress, which requires further study.
Contact‐dependent, polarized acidification response during neutrophil–epithelial interactions
Ian M. Cartwright, Alexander S. Dowdell, Camila Hanson, Rachael E. Kostelecky, Nichole Welch, Calen A. Steiner, Sean P. Colgan
Version of Record online:08 June 2022
Graphical Abstract
Inflammatory acidosis represents a polarized neutrophil-epithelial dependent response independent of myeloperoxidase and ion efflux.
Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions
Weiwei Fu, Wenyan Wang, Jing zhang, Yang Zhao, Keyan Chen, Ye Wang, Jing Zhang, Ying Xiong, Xiaohuan Guo, Shigang Ding
Version of Record online:03 June 2022
Graphical Abstract
A trajectory analysis of circulating ILCs and adaptive T cell lymphocytes subtypes in patients spanning a cascade of gastric lesions.
IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class‐switched antibodies and germinal center B cells upon rechallenge with P. yoelii
Susie L. Brown, Jonathan J. Bauer, Juhyung Lee, Enatha Ntirandekura, Jason S. Stumhofer
Version of Record online:03 June 2022
Graphical Abstract
IgM+ and IgM- MBCs that co-express CD73 and CD80 can differentiate into plasmablasts and germinal center B cells after re-challenge with P. yoelii.
BRAF‐V600E utilizes posttranscriptional mechanisms to amplify LPS‐induced TNFα production in dendritic cells in a mouse model of Langerhans cell histiocytosis
Danielle Minichino, Kaosheng Lv, Niansheng Chu, Wei Tong, Edward M Behrens
Version of Record online:01 June 2022
Graphical Abstract
Hyperactive ERK signaling alters the DC translatome and TACE activity to amplify inflammatory responses to TLR4 stimuli, potentially contributing to inflammation in Langerhans Cell Histiocytosis in mice.